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Wirkung von Nikotin und Amphetamine auf die Regulation des Körpergewichts

L'effet du nicotine et de l'amphetamine sur la régulation du poids

Effects of nicotine and amphetamine on body weight regulation

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Sozial- und Präventivmedizin

Résumé

Le traîtement de nicotine ou de 1'amphetamine durant 6 semaines, produit une stabilisation du poids corporel à un niveau au dessous de celui des controles. Ceci se passe par une hypophagie passagère chez des animaux normaux et par une hyperphagie temporaire chez des animaux maigris préalablement.

Ces effets confirment l'hypothèse de Powley et Keesey (2), disant que le “set-point” du poids sera régulé et pas la prise de la nourriture.

Summary

Twice daily s.c. injections of nicotine or amphetamine, for 6 weeks, produced a stabilization of the body weight at a level below that of the controls. This is attained by a transient hypophagia in normal animals and by a brief hyperphagia in animals emaciated prior to the treatment period.

These effects confirm the hypothesis of Powley and Keesey (2) that the set-point for body weight is regulated, and not food intake.

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Literatur

  1. MUENSTER G., BAETTIG K.: Nicotine-induced hypophagia and hypodipsia in deprived and hypothalamically stimulated rats. Psychopharmacol.41,211–217 (1975)

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  2. POWLEY T.L., KEESEY R.E.: Relationship of body weight to the lateral hypothalamic feeding syndrome. J.Comp.Physiol.Psychol.70,25–36 (1970)

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  3. HOEBEL B.G., TEITELBAUM P.: Weight regulation in normal and hypothalamic hyperphagic rats. J.Comp.Physiol.Psychol.61, 189–193 (1966)

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Classen, W., Bättig, K. Wirkung von Nikotin und Amphetamine auf die Regulation des Körpergewichts. Soz Präventivmed 22, 197–198 (1977). https://doi.org/10.1007/BF02078757

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  • DOI: https://doi.org/10.1007/BF02078757

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