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Acta Neurochirurgica

, Volume 87, Issue 1–2, pp 76–78 | Cite as

The study of the effect of human chorionic gonadotrophic (HCG) hormone on the survival of adrenal medulla transplant in brain. Preliminary study

  • A. Patil
  • K. Fillmore
  • J. Valentine
  • D. Hill
Article

Summary

Autologous adrenal cortex was completely dissected off the medula using microdissection. The adrenal medulla tissue was transplanted to the lateral ventricle in twenty-one adult rats. Group A consisting of ten animals received 200 units of HCG per 100 gram body weight daily for one week and then on every alternate day for seven weeks. The remaining rats (group B) served as control. After eight weeks the brains were removed and a volumetric study was done using histological sections. High pressure liquid chromatography (HPLC) with electrochemical detection for catecholamine assay of the graft was also undertaken. The graft survival in group A was significantly higher (p<0.005) than group B. The level of norepinephrine was significantly higher in group A while dopamine was higher in group B. The higher volume of graft tissue in group A suggests that HCG may help in increased survival and growth of the transplanted tissue. Higher levels of norepinephrine in group A would suggest a tendency for such grafts to be active to a greater extent with the treatment of HCG.

Keywords

Adrenal medulla transplant CNS transplantation catecholamine human chorionic gonadotrophic hormone 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Patil
    • 1
  • K. Fillmore
    • 1
  • J. Valentine
    • 2
  • D. Hill
    • 2
  1. 1.Division of NeurosurgeryOral Roberts University, School of Medicine, City of Faith Medical and Research CenterTulsaUSA
  2. 2.Department of PharmacologyOral Roberts University, School of Medicine, City of Faith Medical and Research CenterTulsaUSA

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