Pharmaceutisch Weekblad

, Volume 9, Supplement 1, pp S76–S77 | Cite as

Treatment of multi-resistant urinary tract infections in patients with multiple sclerosis

  • H. van Poppel
  • L. Baert


Multi-resistant nosocomial urinary tract infections occurring in thirty patients with neurogenic bladder dysfunction were treated with ciprofloxacin 100 mg twice daily Early bacteriological eradication was obtained in 48.3%, persistence in 34.5% and superinfection in 17.2%. Recurrence, 30 days after initial eradication occurred in 50% while late eradication was maintained in 35% and reinfection with another germ was noted in 15%. Most recurring and reinfecting germs were still susceptible to ciprofloxacin.

The drug was well tolerated. The overall outcome was mainly determined by the vesico-urethral dysfunction itself and by the presence of indwelling bladder catheters.

Key words

Nosocomial infection Multiple sclerosis Quinolones Urinary tract infection 


  1. 1.
    Van Poppel H, Wegge M. Pseudomonas infections in Multiple Sclerosis. Antonie van Leeuwenhoek Microbiol 1984;50:293–5.Google Scholar
  2. 2.
    Van Poppel H, Vereecken RL, Leruitte A. Neuro-muscular dysfunction of the lower urinary tract in Multiple Sclerosis. Paraplegia 1983;21:374–9.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1987

Authors and Affiliations

  • H. van Poppel
    • 1
  • L. Baert
    • 1
  1. 1.Urology DepartmentUniversity Clinics of the Katholieke Universiteit LeuvenBelgium

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