Influence of dose frequency on the therapeutic efficacies of ciprofloxacin and ceftazidime in experimental Klebsiella pneumoniae pneumonia and septicemia in relation to their bactericidal activities in vitro
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The antibacterial activities of ciprofloxacin versus ceftazidime againstKlebsiella pneumoniae in vitro andin vivo were compared. Although there was only a minor difference in MBC values between both drugs ciprofloxacin demonstrated a high and dose-dependent bacterial killing ratein vitro and in lungs of leukopenic rats in contrast to the more time-dependent bactericidal activity of ceftazidime. After treatment of aK.pneumoniae pneumonia and septicemia the efficacy of ciprofloxacin was only slightly influenced by the mode of administration, either at 6-h intervals or continuously, whereas ceftazidime was far more effective after continuous administration. This resulted in a superior efficacy of ciprofloxacin after intermittent treatment as compared to ceftazidime, whereas ceftazidime was more effective after continuous administration as compared to ciprofloxacin. Also ciprofloxacin proved to be bactericidal against bacteria that were not actively growing, bothin vitro andin vivo, whereas ceftazidime was not.
Key wordsAntibiotic dose schedule Ceftazidime Ciprofloxacin Klebsiella pneumoniae
- 1.Klastersky J, Glauser MP, Schimpff SC, Zinner SH, Gaya H, and The European Organization for Research on Treatment of Cancer antimicrobial therapy project group. Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrob Agents Chemother 1986;29:263–70.PubMedGoogle Scholar
- 8.Thonus IP, de Lange-Macdaniel AV, Otte CJ, Michel MF. Tissue cage infusion: a technique for the achievement of prolonged steady stage in experimental animals. J Pharmacol Methods 1979;2:63–9.Google Scholar
- 9.Sachs L. Evaluation of biologically active substances based on dosage — dichotomous effect curves. In: Sachs L, ed. Applied statistics. A handbook of techniques. New York: Springer Verlag, 1982;224–8.Google Scholar