Pediatric Radiology

, Volume 20, Issue 6, pp 464–468 | Cite as

Changes in T1 relaxation processes in the bone marrow following treatment in children with acute lymphoblastic leukemia

A magnetic resonance imaging study
  • K. E. Jensen
  • C. Thomsen
  • O. Henriksen
  • H. Hertz
  • H. K. Johansen
  • M. Yssing


Magnetic resonance imaging (MRI) and T1 relaxation time measurements of the vertebral bone marrow were performed in 11 children with acute lymphoblastic leukemia (ALL) at diagnosis. Nine of the children were re-examined after chemotherapeutic treatment. The results were compared with histological data from bone marrow biopsies obtained in close association to the MR examinations. Ten age matched children were examined as a control group. A 1.5 Tesla whole body scanner was used for the measurements. The pretreatment T1 relaxation times of the bone marrow were significantly prolonged, compared to the age matched controls. After chemotherapy the T1 relaxation times of the children with ALL decreased significantly towards or into the normal range. A significant correlation was found between the T1 relaxation time and the content of malignant blast cells in the bone marrow.


Bone Marrow Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Bone Marrow Biopsy Blast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. E. Jensen
    • 1
  • C. Thomsen
    • 1
  • O. Henriksen
    • 1
  • H. Hertz
    • 2
  • H. K. Johansen
    • 2
  • M. Yssing
    • 2
  1. 1.Department of Magnetic Resonance, Hvidovre HospitalUniversity of CopenhagenCopenhagenDenmark
  2. 2.Department of Pediatrics, RigshospitaletUniversity of CopenhagenDenmark

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