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Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives

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Abstract

In this study the preparation of five hydrophilic derivatives of sulfadiazine is reported. The common structural element in the compounds is the 2-sulfonamidopyrimidine moiety. Three of these compounds are suitable for the preparation of a photostable 1∶1 silver compound. These silver compounds are five to ten times more water soluble than silver sulfadiazine. TheIr,1H- and13C-Nmr data point to a similar co-ordination of silver in these compounds as with silver sulfadiazine. The microbiological activity of these silver compounds againstSt. aureus is slightly lower.

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Authors and Affiliations

  1. Department of Pharmaceutical Analysis and Analytical Chemistry, Subfacuity of Pharmacy, University of Leiden, P. O. Box 9502, 2300, RA Leiden, The Netherlands

    P. P. De Wit & A. Bult

  2. Department of Pharmaceutical Technology, Subfaculty of Pharmacy, University of Leiden, P.O. Box 9502, 2300, RA Leiden, The Netherlands

    H. Van Doorne

Authors
  1. P. P. De Wit
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  2. H. Van Doorne
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  3. A. Bult
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In honour of Professor Faber on the occasion of his 25-years' professorate.

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De Wit, P.P., Van Doorne, H. & Bult, A. Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives. Pharmaceutisch Weekblad Scientific Edition 5, 298–301 (1983). https://doi.org/10.1007/BF02074858

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  • DOI: https://doi.org/10.1007/BF02074858

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