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Intracranial tuberculosis in the Netherlands: Four paediatric cases

  • Infectious Diseases
  • Original Paper
  • Published:
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Abstract

Abstract

Since 1987 a resurgence of tuberculosis is occurring in the Netherlands in analogy to the situation in other industrialised countries. So far this has not been associated with an increased incidence of tuberculous meningitis, which is still a rare complication of the disease. Four cases of intracranial tuberculosis were recently diagnosed in our hospital. All children were from middle-class Dutch families with no identified risk for tuberculosis. An extensive contact identification search could identify a contact in two patients. Two children were in an advanced stage of disease before diagnosis. Skin tests were repeatedly negative in all cases which delayed treatment in two cases for almost 2 weeks. One patient developing a cerebral tuberculous focus during therapy responded well to a second course of corticosteroids. Three children developed severe neurological sequelae.

Conclusion

This report illustrates that suspicion of intracranial tuberculosis is warranted in the case of an ill-defined inflammatory neurological syndrome.

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Abbreviations

AFB :

acid-fast bacillus

PCR :

polymerase chain reaction

PPD :

purified protein derivate

TBM :

tuberculous meningitis

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Authors and Affiliations

  1. Department of Paediatrics, Beatrix Children's Hospital, University Hospital Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands

    J. B. M. van Woensel, C. G. Hoogeveen, G. Visser & J. L. L. Kimpen

  2. Department of Neurology, University Hospital Groningen, The Netherlands

    J. H. Begeer

Authors
  1. J. B. M. van Woensel
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  2. C. G. Hoogeveen
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  3. J. H. Begeer
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  4. G. Visser
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  5. J. L. L. Kimpen
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van Woensel, J.B.M., Hoogeveen, C.G., Begeer, J.H. et al. Intracranial tuberculosis in the Netherlands: Four paediatric cases. Eur J Pediatr 154, 546–550 (1995). https://doi.org/10.1007/BF02074832

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  • DOI: https://doi.org/10.1007/BF02074832

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