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Histamine dependent cAMP generating system in rabbit CNS: interaction with various neuroregulators

  • Histamine and the Central Nervous System
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Abstract

Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in slices of the rabbit cerebral cortex (EC50: 15 μM; maximum stimulation: 300–450% of the basal level). Combination ofl-noradrenaline orl-adrenaline and adenosine with HI showed synergistic and additive effects, respectively. Carbachol, arecoline and pilocarpine had no effect, while oxotremorine and tremorine increased and decreased the HI response when used at low or high concentrations, respectively.

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Authors and Affiliations

  1. Department of Biogenic Amines, Polish Acad. Sci., 90-136, Lodz, Poland

    B. Sek, A. Sebastjanska & J. Z. Nowak

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  1. B. Sek
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  2. A. Sebastjanska
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  3. J. Z. Nowak
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Sek, B., Sebastjanska, A. & Nowak, J.Z. Histamine dependent cAMP generating system in rabbit CNS: interaction with various neuroregulators. Agents and Actions 20, 244–247 (1987). https://doi.org/10.1007/BF02074681

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