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, Volume 20, Issue 3–4, pp 244–247 | Cite as

Histamine dependent cAMP generating system in rabbit CNS: interaction with various neuroregulators

  • B. Sek
  • A. Sebastjanska
  • J. Z. Nowak
Histamine and the Central Nervous System

Abstract

Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in slices of the rabbit cerebral cortex (EC50: 15 μM; maximum stimulation: 300–450% of the basal level). Combination ofl-noradrenaline orl-adrenaline and adenosine with HI showed synergistic and additive effects, respectively. Carbachol, arecoline and pilocarpine had no effect, while oxotremorine and tremorine increased and decreased the HI response when used at low or high concentrations, respectively.

Keywords

Adenosine Histamine Cerebral Cortex Generate System Carbachol 

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • B. Sek
    • 1
  • A. Sebastjanska
    • 1
  • J. Z. Nowak
    • 1
  1. 1.Department of Biogenic AminesPolish Acad. Sci.LodzPoland

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