Agents and Actions

, Volume 20, Issue 3–4, pp 244–247 | Cite as

Histamine dependent cAMP generating system in rabbit CNS: interaction with various neuroregulators

  • B. Sek
  • A. Sebastjanska
  • J. Z. Nowak
Histamine and the Central Nervous System


Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in slices of the rabbit cerebral cortex (EC50: 15 μM; maximum stimulation: 300–450% of the basal level). Combination ofl-noradrenaline orl-adrenaline and adenosine with HI showed synergistic and additive effects, respectively. Carbachol, arecoline and pilocarpine had no effect, while oxotremorine and tremorine increased and decreased the HI response when used at low or high concentrations, respectively.


Adenosine Histamine Cerebral Cortex Generate System Carbachol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    J. W. Daly,Cyclic Nucleotides in the Nervous System. Plenum Press, New York 1977.Google Scholar
  2. [2]
    P. D. Kanof and P. Greengard,Pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain. J. Pharmacol. exp. Ther.209, 87–96 (1979).PubMedGoogle Scholar
  3. [3]
    J. M. Palacios, M. Garbarg, G. Barbin and J. C. Schwartz,Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea pig hippocampus. Mol. Pharmacol.14, 971–982 (1978).PubMedGoogle Scholar
  4. [4]
    J. W. Daly, E. T. McNeal and C. R. Creveling,Accumulation of cyclic AMP in brain tissue: role of H 1-and H 2-histamine receptors. In:Histamine Receptors (Ed. T. O. Yellin, Spectrum, New York 1979), pp. 299–323.Google Scholar
  5. [5]
    U. Schwabe, Y. Ohga and J. W. Daly,The role of calcium in the regulation of cyclic nucleotide levels in brain slices of rat and guines pig. Naunyn-Schmiedeberg's Arch. Pharmacol.302, 141–151 (1978).Google Scholar
  6. [6]
    B. L. Brown, J. D. D. Albano, R. P. Ekins, A. M. Sgherzi and W. Tampion,A simple and sensitive saturation assay method for measurement of adenosine 3′,5′-cyclic monophosphate. Biochem. J.121, 561–562 (1971).PubMedGoogle Scholar
  7. [7]
    M. Al-Gadi and S. J. Hill,Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. Br. J. Pharmac.85, 877–888 (1985).Google Scholar
  8. [8]
    S. Kakiuchi and T. W. Rall,Studies on adenosine 3′,5′-phosphate in rabbit cerebral cortex. Mol. Pharmacol.4, 379–388 (1968).PubMedGoogle Scholar
  9. [9]
    P. R. Daum, S. J. Hill and J. M. Young,Histamine H 1-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parameters. Br. J. Pharmac.77, 347–355 (1982).Google Scholar
  10. [10]
    E. B. Hollingsworth and J. W. Daly,Accumulation of inositolphosphates and cyclic AMP in guinea-pig cerebral cortical preparations. Effects of norepinephrine, histamine, carbamylcholine and 2-chloroadenosine. Biochim. biophys. Acta857, 207–216 (1985).Google Scholar

Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • B. Sek
    • 1
  • A. Sebastjanska
    • 1
  • J. Z. Nowak
    • 1
  1. 1.Department of Biogenic AminesPolish Acad. Sci.LodzPoland

Personalised recommendations