Agents and Actions

, Volume 20, Issue 3–4, pp 191–193 | Cite as

On the interaction of local anesthetics with mast cells

  • K. Drábiková
  • R. Nosál
Histamine Release

Abstract

The carbanilate local anesthetics carbisocaine, heptacaine and pentacaine liberate histamine from isolated rat mast cells. Procaine, carticaine, trimecaine, cocaine and butanilicaine were ineffective. Histamine liberation was dose-dependent, followed by calcium displacement from membrane binding sites and occured without concomitant degranulation. Low temperature and pH-dependent inhibition of histamine liberation indicated a non-specific, membrane perturbing effect of highly liposoluble carbanilate local anesthetics. Conformational changes in the sodium channel on the mast cell membrane induced by carbanilate anesthetics might result in histamine exchange occuring intracellularly.

Keywords

Cocaine Mast Cell Histamine Conformational Change Local Anesthetic 

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • K. Drábiková
    • 1
  • R. Nosál
    • 1
  1. 1.Institute of Experimental Pharmacology, Centre of Physiological SciencesSlovak Academy of SciencesBratislavaCzechoslovakia

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