Summary
Incomplete cerebral ischaemia of 10 to 60 minutes duration was performed by reducing the perfusion pressure of completely isolated canine heads at brain temperatures of 37 and 32 °C. Complete cerebral ischaemia of the same duration was performed by complete stopping of the perfusion. The latency of recovery of the electrocorticogram,i.e. the time interval from the end of the cerebral ischaemia until reappearance of the first spontaneous cortical potentials, was shorter after incomplete ischaemia than after complete ischaemia. At 37 °C brain temperature the latency of recovery of the electrocorticogram was zero after a perfusion of the brain with a perfusion pressure of 22 mm Hg for 1 hour. After an incomplete ischaemia of 1 hour produced by a perfusion pressure of 20 mm Hg the latency of recovery was 0 to 4 minutes. Lower perfusion pressures increased the latency of recovery considerably. Reduction of brain temperature to 32 °C decreased the latency of recovery. At perfusion pressures of 22 mm or more there was no difference in the latency of recovery between 37 and 32 °C brain temperature.
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Baldy-Moulinier, M., Ischémies cérébrales expérimentales. Rev. Electroencephalogr. Neurophysiol. Clin.4 (1974), 334–343.
Boyd, R. J., Connolly, J. E., Tolerance of anoxia of the dog's brain at various temperatures. Surg. Forum12 (1962), 408–412.
Branston, N. M., Symon, L., Crockard, H. A., Pásztor, E., Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp. Neurol.45 (1974), 195–208.
Brierley, J. B., Brown, A. W., Excell, B. J., Meldrum, B. S., Brain damage in the rhesus monkey resulting from profound arterial hypotension. I. Its nature, distribution and general physiological correlates. Brain Res.13 (1969), 68–100.
Brierly, J. B., Excell, J., The effect of profound systemic hypotension upon the brain of m. rhesus: Physiological and pathological observations. Brain89 (1966), 269–298.
Brockman, S. K., Jude, J. R., The tolerance of the dog brain to total arrest of circulation. Bull. Johns Hopkins Hosp.106 (1960), 74–80.
Cantu, R. C., Ames III, A., di Giacinto, G., Dixon, J., Hypotension: A major factor limiting recovery from cerebral ischemia. J. Surg. Res.9 (1969), 525–529.
Golden, P. F., Jane, J. A., Experimental study of irreversible shock and the brain. J. Neurosurg.39 (1973), 434–441.
Hirsch, H., Bolte, A., Schaudig, A., Tönnis, D., Über die Wiederbelebung des Gehirns bei Hypothermie. Pflügers Arch. ges. Physiol.265 (1957), 328–336.
Hirsch, H., Tesch, P., Recovery of the electrocorticogram of canine brains after complete cerebral ischemia at 37 °C and 32 °C. Neurosurg. Rev., in press.
Hossmann, K. A., Zimmermann, V., Resuscitation of the monkey brain after 1 h complete ischemia. I. Physiological and morphological observations. Brain Res.81 (1974), 59–74.
Marshall, L. F., Durity, F., Lounsbury, R., Graham, D. I., Welsh, F., Langfitt, T. W., Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part I: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier and neurological function. J. Neurosurg.43 (1975 a), 308–317.
Marshall, L. F., Graham, D. I., Durity, F., Lounsbury, R., Welsh, F., Langfitt, T. W., Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 2: Brain morphology. J. Neurosurg.43 (1975 b), 318–322.
Marshall, S. B., Owens, J. C., Swan, H., Temporary circulatory occlusion to the brain of the hypothermic dog. Arch. Surg.72 (1957), 98–106.
Nordström, C. H., Rehncrona, St., Siesjö, B. K., Restitution of cerebral energy state after complete and incomplete ischemia of 30 min duration. Acta physiol. Scand.97 (1976), 270–272.
Nordström, C. H., Rehncrona, S., Siesjö, B. K., Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after 30 minutes of complete ischemia in rats anaesthetized with nitrous oxide or phenobarbital. J. Neurochem.30 (1978), 479–486.
Pertuiset, B., Goutorbe, J., Caruel, N., van Effenterre, R., Horn, Y. E., L'hypotension profonde préventive par arfonad ou nitroprussiate de soude durant l'abord de 66 anévrysmes sacciformes sus-tentoriels. Neuro-Chirurgie20 (1974), 555–564.
Pertuiset, B., Houtteville, J.-P., van Effenterre, R., Caruel, N., Goutorbe, J., Chirurgie des anévrysmes artériels sus-tentoriels. Réduction par coagulation bipolaire sous hypotension profonde et exclusion par clip autobloquant (52 cas opérés sous microscope). Nouv. Presse Med.3 (1974), 1649–1652.
Salford, L. G., Siesjö, B. K., The influence of arterial hypoxia and unilateral carotid artery occlusion upon regional blood flow and metabolism in the rat brain. Acta physiol. Scand.92 (1974), 130–141.
Simeone, F. A., Witoszka, M., The central nervous system in the experimental hemorrhagic shock. Amer. J. Surg.119 (1970), 427–432.
Steen, A., Michenfelder, J. D., Milde, J. H., Incomplete versus complete cerebral ischemia: Improved outcome with a minimal blood flow. Ann. Neurol.6 (1979), 389–398.
Terlecki, S., Baldwin, B. A., Bell, F. R., Experimental cerebral ischaemia in sheep. Acta Neuropath.7 (1967), 185–200.
Trojaberg, W., Boysen, G., Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy. Electroenceph. Clin. Neurophysiol.34 (1973), 61–69.
Wright, R. L., Experimental cerebral ischemia. Physiol. Angiologie16 (1965), 397–404.
Yashon, D., Locke, G. E., Bingham, G., Jr., Wiederholt, W. C., Hunt, W. E., Cerebral function during profound oligemic hypotension in the dog. J. Neurosurg.34 (1971), 494–499.
Young, W. P., Javid, M., Study of the use of intravenous urea after stimulated cardiac arrest in dogs. Surg. Forum10 (1960), 522–524.
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Hirsch, H. Recovery of the electrocorticogram after incomplete and complete ischaemia of the brain. Acta neurochir 66, 147–158 (1982). https://doi.org/10.1007/BF02074501
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DOI: https://doi.org/10.1007/BF02074501