Summary
1. Recent data have shown that interleukin-10 (IL-10) is expressed and acts in mouse pituitary tumor cells and freshly isolated mouse pituitaries.
2. In this study, we show that poly(A+ RNA derived from normal human pituitary and hypothalamus expresses IL-10 message.
3. The majority of transcripts was likely from the pituitary and hypothalamus, and not from lymphocytes in the pituitary and hypothalamic vasculature, since both IL-10 and interferon-γ mRNA levels, compared to equivalent amounts of RNA from peripheral blood lymphocytes, were much lower.
4. These results indicate that IL-10 may function in human neuroendocrine processes as it does in the murine system, thus serving as an important signal molecule for bidirectional communication between the neuroendocrine and the immune systems.
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Rady, P.L., Smith, E.M., Cadet, P. et al. Presence of interleukin-10 transcripts in human pituitary and hypothalamus. Cell Mol Neurobiol 15, 289–296 (1995). https://doi.org/10.1007/BF02073335
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DOI: https://doi.org/10.1007/BF02073335