Summary
1. The morphology of neurons in the dentate gyrus of the adult human brain was analyzed with two variants of Golgi technique.
2. About 20 neuronal types and subtypes were observed in the dentate gyrus of the adult human, several of which had not previously been described in the human. The human dentate gyrus harbors 4 types of neurons in the molecular layer, 3 types within the granule cell layer, and at least 10 types in the hilus.
3. Compared to the granule neurons in the rat brain, human granule neurons show a much greater variability. Many of these human neurons have basal dendrites and/or axonal spines. Also, there are significant differences among these neurons regarding the density of their dendritic trees and dendritic spines. In contrast to the rat, human hilar neurons with complex spines have complex spines not only on their dendrites but also on their cell bodies.
4. This study opens the door for further morphological studies involving specific diseases such as Alzheimer's disease and epilepsy.
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References
Amaral, D. G. (1978). A Golgi study of cell types in the hilar region of the hippocampus in the rat.J. Comp. Neurol. 182851–914.
Braak, H. (1974). On the structure of the human archicortex: The cornu ammonis.Cell Tissue Res. 152349–383.
Braak, E., Strotkamp, B., and Braak, H. (1991). Parvalbumin-immunoreactive structures in the hippocampus of the human adult.Cell Tissue Res. 26433–48.
Braitenberg, V., Guglielmotti, V., and Sada, E. (1967). Correlation of crystal growth with the staining of axons by the Golgi procedure.Stain Technol. 24277–283.
Desmond, N. L., and Levy, W. B. (1985). Granule cell dendritic spine density in the rat hippocampus varies with spine shape and location.Neurosci. Lett. 54219–224.
Fox, G. A., Ubeda-Purkiss, M., Ihrig, H. K., and Biagioli, D. (1951). Zinc chromate modification of the Golgi technique.Stain Technol. 26109–114.
Frotscher, M., and Zimmer, J. (1983). Lesion-induced mossy fibers to the molecular layer of the rat fascia dentata: Identification of postsynaptic granule cells by the Golgi-EM technique.J. Comp. Neurol. 215299–311.
Frotscher, M., Kraft, J., and Zorn, U. (1988). Fine structure of identified neurons in the primate hippocampus: A combined Golgi/EM study in the baboon.J. Comp. Neurol. 275254–270.
Ribak, C. E., and Seress, L. (1983). Five types of basket cell in the hippocampal dentate gyrus: A combined Golgi and electron microscopic study.J. Neurocytol. 12577–597.
Ribak, C. E., and Seress, L. (1988). A Golgi-electron microscopic study of fusiform neurons in the hilar region of the dentate gyrus.J. Comp. Neurol. 27167–78.
Seay-Lowe, S. L., and Claiborne, B. J. (1992). Morphology of intracellularly labeled interneurons in the dentate gyrus of the immature rat.J. Comp. Neurol. 32423–36.
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Al-Hussain, S., Al-Ali, S. A golgi study of cell types in the dentate gyrus of the adult human brain. Cell Mol Neurobiol 15, 207–220 (1995). https://doi.org/10.1007/BF02073329
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DOI: https://doi.org/10.1007/BF02073329