Abstract
Eight children aged between 1.3 and 13 years suffering from epilepsy refractory to conventional anticonvulsive therapy were treated with high dose intravenous gamma globulin (200 mg/kg, 3 times per week, repeated after 3 weeks). Immunological studies after therapy showed normal results. In four children, clinical and EEG findings markedly improved. In one other case a partial response was noted. No improvement was observed in the remaining three cases. We confirm that although the mechanism is still obscure, high doses of i.v. gammaglobulin may have a beneficial effect in a significant number of children with intractable epilepsy.
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Abbreviations
- IVIG:
-
intravenous gamma globulin
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Etzioni, A., Jaffe, M., Pollack, S. et al. High dose intravenous gamma-globulin in intractable epilepsy of childhood. Eur J Pediatr 150, 681–683 (1991). https://doi.org/10.1007/BF02072634
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DOI: https://doi.org/10.1007/BF02072634