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Heart and Vessels

, Volume 1, Supplement 1, pp 111–115 | Cite as

Myocardial bioptic findings in correlation with TL-201 imaging and hemodynamic parameters in patients with latent cardiomyopathies suspected of having myocarditis

  • Siegfried Müller
  • Paul Müller
  • Rudolf Meyer
  • Hans Volkmann
  • Dietmar Gottschild
  • Klaus Thoss
  • Gabriele Kalhöfer
  • Gerhard Wessel
Viral And Other Myocarditis

Summary

Sixty-eight patients (24 males, 44 females, mean age 37.2 years) belonging to NYHA classes I and II were investigated. All patients had a nondilated ventricle as well as hemodynamic criteria of “latent cardiomyopathy.”

In 78% of the patients, a high susceptibility to infection, frequent angina, or possible myocarditis were found. In 75.5%, the mean pulmonary artery pressure was abnormal. T1-201 scintigraphy revealed perfusion defects in 78%. Dyskinesia or hypokinesia were found in 52%. The left ventricular ejection fraction was normal in 74%.

On biopsy, pathologic findings were detected in 60.9% of patients with a high frequency of hypertrophy and fibrosis (50%). In two patients, lymphocytic infiltrates were found. Immunohistologically, deposits of complement, IgG, IgM, and gammaglobulin, mainly in the sarcolemma, could be identified in 19.1% of cases. The myocardium was normal in 39.1%; insufficient material was found in 5.9% of patients.

Morphologic, scintigraphic, and hemodynamic findings could not be correlated but the combination of two pathologic parameters permitted diagnosis. Biopsy was the most effective diagnostic method in myocarditis.

Keywords

Left Ventricular Ejection Fraction Myocarditis Perfusion Defect Left Ventricular Ejection Pulmonary Artery Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Siegfried Müller
    • 1
  • Paul Müller
    • 1
  • Rudolf Meyer
    • 1
  • Hans Volkmann
    • 1
  • Dietmar Gottschild
    • 1
  • Klaus Thoss
    • 1
  • Gabriele Kalhöfer
    • 1
  • Gerhard Wessel
    • 1
  1. 1.Abteilung für KardiologieKlinik für Innere Medizin der Friedrich-Schiller-UniversitätJenaGerman Democratic Republic

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