Heart and Vessels

, Volume 1, Supplement 1, pp 23–29 | Cite as

Myocarditis in autopsy

  • Ryozo Okada
  • Shigeo Wakafuji
Myocarditis, Cardiomyopathy And Related Disorders


In the Annuals of Autopsy Records for Japan from 1958 to 1977, 377 841 autopsy cases were registered; a short summary of pathologic findings was included. Of the 377 841 cases, 409 (0.11%) were registered as idiopathic, nonspecific, interstitial, or viral myocarditis and 25 cases (0.007%) as giant-cell myocarditis. The annual incidence of the myocarditis varied at 5-year intervals and a remarkable increase was observed after 1974. An analysis of 19 cases of myocarditis and 19 of postmyocarditic cardiomegaly (PMC) showed a preponderance of males. Dilatation of ventricles was found in all cases of acute, subacute, and healing myocarditis, which histologically showed interstitial mononuclear cell infiltration, necrosis, and disarray of myocytes. Hypertrophy with ventricular dilatation, ventricular dilatation without hypertrophy, endo- or epicardial involvement, and right ventricular lipomatosis were found in 70%, 20%, 30%, and 10% of cases with chronic myocarditis and PMC, respectively. In these cases, residual inflammation, fibrosis, and hypertrophy was observed histologically.


Mononuclear Cell Vascular Surgery Interventional Radiology Pathologic Finding Myocarditis 
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  1. 1.
    The annuals of autopsy records in Japan (in Japanese). Edited by the Japanese Society of Pathology, Tokyo, 1959–1978, (Vol. I–XX)Google Scholar
  2. 2.
    Okada R (1983) Pathological statistics of cardiomyopathies using the annuals of autopsy cases in Japan during 20 year period. In: Toshima H (ed) The 1982 annual report of the study group of idiopathic cardiomyopathy. Sponsored by the Ministry of Health and Welfare (in Japanese). Kurume University School of Medicine, Kyushu, pp 28–34Google Scholar
  3. 3.
    Okada R (1978) Myocarditis. In: Yoshitoshi Y, et al (eds) New Handbook of Internal Medicine (in Japanese). Nakayama Shoten, Tokyo, 35A, pp 51–86.Google Scholar
  4. 4.
    Corby C (1960) Isolated myocarditis as a cause of sudden obscure death. Med Sci Law 1: 23–40Google Scholar
  5. 5.
    Knieriem HJ (1978) Morphologic changes of the myocardium induced by different toxic agents. In: Kaltenbach M, Loogen F, Olsen EGJ (ed) Cardiomyopathy and myocardial biopsy. Springer, Berlin Heidelberg New York, pp 2–11Google Scholar
  6. 6.
    Okada R, Nasu T (1970) Idiopathic myocardiopathy and allied cardiac diseases. Pathol Microbiol 35: 56–69Google Scholar
  7. 7.
    Okada R (1971) A morphological classification of the idiopathic myocardiopathy and allied cardiac diseases. Jpn Circ J 35: 755–763Google Scholar
  8. 8.
    Goodwin JF (1982) The frontiers of cardiomyopathy. Br Heart J 48: 1–18Google Scholar
  9. 9.
    Zee-cheng C, Tsai CC, Palmer DC, Codd JE, Pennington DG, Williams GA (1984) High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Casdiol 3: 63–70Google Scholar
  10. 10.
    Okada R (1980) Pathomorphological aspects of cardiomyopathies. In: Sekiguchi M, Olsen EGJ (eds) Cardiomyopathy: Clinical, pathological and theoretical aspects. University of Tokyo Press, Tokyo, and University Park Press, Baltimore, pp. 79–88Google Scholar
  11. 11.
    Fontaine G, Guiraudon G, Frank R, Vedel J, Grosgogeat Y, Cabrol C (1978) Modern concepts of ventricular tachycardia. Eur J Cardiol 8: 565–580Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Ryozo Okada
    • 1
  • Shigeo Wakafuji
    • 2
  1. 1.Research Laboratory for Cardiovascular PathologyJuntendo University School of MedicineTokyoJapan
  2. 2.Department of PathologyJuntendo University School of MedicineTokyoJapan

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