European Journal of Pediatrics

, Volume 149, Issue 12, pp 835–844 | Cite as

Neurological outcome in high risk weight appropriate for gestational age preterm children at early school age

  • R. H. Largo
  • L. Molinari
  • S. Kundu
  • U. Hunziker
  • G. Duc
Growth and Development


Neurological development in preterm children with birth weight appropriate for gestational age is reported in two separate groups: a longitudinal study of 97 preterm children and 93 term children as a control group and a cross-sectional study of 249 preterm children. Both preterm groups were regarded as high risk with respect to number of outborns, distribution of gestational age and perinatal risk factors. Neurological outcome at 5–6 years of age in the majority of the preterm children was comparable to that of the term children. However, 15% of boys and 9% of girls in the preterm group were diagnosed as having cerebral palsy. Mild diplegia was most frequently observed; 4% of the children were severely impaired. Fourteen percent of the preterm vs 2% of the term boys and 6–9% of the preterm vs none of the term girls received motor therapy during early school age. There was a small but consistent sex difference in neurological outcome in favour of the term and preterm girls. Effects of drop out rate and of incompleteness of ascertainment are reported in detail.

Key words

Preterm children Neurological development Cerebral palsy 5–6 Years of age 



weight appropriate for gestational age


cerebral palsy


cross-sectional study


longitudinal study


socio-economic status


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. H. Largo
    • 1
  • L. Molinari
    • 2
  • S. Kundu
    • 1
  • U. Hunziker
    • 3
  • G. Duc
    • 2
  1. 1.Drowth and Development CentreUniversitäts-Kinderspital ZürichZürichSwitzerland
  2. 2.Department of PaediatricsUniversitäts-Kinderspital ZürichZürichSwitzerland
  3. 3.KinderspitalWinterthurSwitzerland

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