European Journal of Pediatrics

, Volume 150, Issue 2, pp 97–99 | Cite as

False diagnosis of non-A/non-B hepatitis hiding two cases of cystic fibrosis

  • M. Resti
  • C. Adami Lami
  • F. Tucci
  • F. Mannelli
  • M. E. Rossi
  • C. Azzari
  • A. Vierucci
Infectious Diseases

Abstract

We report two cases of children followed for many years with an original diagnosis of non-A/non-B hepatitis. One child developed serious cirrhosis with portal hypertension. Long-term observation of the course of their hepatic disease provided the diagnosis of cystic fibrosis. These cases demonstrate that cystic fibrosis though rarely presenting with initial hepatic signs, can manifest itself with only long-term hepatic symptoms. We therefore strongly recommend analysis of sweat chloride concentration in cases of hepatic disease of unknown origin.

Key words

Cystic fibrosis Non-A non-B hepatitis Cirrhosis 

Abbreviation

CF

cystic fibrosis

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References

  1. 1.
    Feigelson J, Pecau Y, Cathelineau L, Navarro J (1975) Additional data on hepatic function tests in cystic fibrosis. Acta Paediatr Scand 64:337–344PubMedGoogle Scholar
  2. 2.
    Gaskin KJ, Waters DLM, Howman-Giles R, De Silva M, Earl JW, Martin HCO, Kan AE, Brown JM, Dorney SFA (1988) Liver disease and common-bile-duct stenosis in cystic fibrosis. N Engl J Med 316:340–346Google Scholar
  3. 3.
    Hultcrantz R, Mengarelli S, Strandvik B (1986) Morfological findings in the liver of children with cystic fïbrosis: a light and electron microscopical study. Hepatology 6:881–889PubMedGoogle Scholar
  4. 4.
    Isenberg J, L'Heureux P, Warwick W, Sharp H (1976) Clinical observation on the biliary system in cystic fibrosis. Am J Gastroenterol 65:134–141PubMedGoogle Scholar
  5. 5.
    Kattwienkel J, Taussig L, Statland B, Verter J (1973) The effect of age on alkaline phosphatase and other serologic liver function tests in normal subjects and patients with cystic fibrosis. J Pediatr 82:234–242PubMedGoogle Scholar
  6. 6.
    Oppenheimer E, Esterly J (1975) Hepatic changes in young infants with cystic fibrosis possible relation to focal biliary cirrhosis. J Pediatr 86:683–689PubMedGoogle Scholar
  7. 7.
    Park RW, Grand RJ (1981) Gastrointestinal manifestation of cystic fibrosis: a review. Gastroenterology 81:1143–1161PubMedGoogle Scholar
  8. 8.
    Patrick MK, Howman-Giles R, De Silva M, Van Asperen P, Pitkin J, Gaskin KJ (1986) Common bile duct obstruction causing right upper abdominal pain in cystic fibrosis. J Pediatr 108:101–102PubMedGoogle Scholar
  9. 9.
    Psacharopoulos HT, Howard ER, Portmann B, Mowat AP, Williams R (1980) Hepatic complications of cystic fibrosis. Lancet II:78–80Google Scholar
  10. 10.
    Roy CC, Weber AM, Morin CL, Lepage G, Brisson G, Yousef I, Lasalle R (1982) Hepatobiliary disease in cystic fibrosis: a survey of current issues and concepts. J Pediatr Gastroenterol Nutr 1:469–478PubMedGoogle Scholar
  11. 11.
    Schuster RS, Scwachman H, Toyama WM, Rubino A, Taik-Khaw K (1977) The management of portal hypertension in cystic fibrosis. J Pediatr Surg 12:201–206PubMedGoogle Scholar
  12. 12.
    Stern RC, Stevens DP, Boat TF, Doershuk CF, Izant RS, Matthews LW (1976) Syntomatic hepatic disease in cystic fibrosis: incidence, course, and outcome of portal systemic shunting. Gastroenterology 70:645–649PubMedGoogle Scholar
  13. 13.
    Valman HB, France NE, Wallis PG (1971) Prolonged neonatal jaundice in cystic fibrosis. Arch Dis Child 46:805–809PubMedGoogle Scholar
  14. 14.
    Wilroy RS, Crawford SE, Johnson WW (1966) Cystic fibrosis with extensive fat replacement of the liver. J Pediatr 68:67–73PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Resti
    • 1
  • C. Adami Lami
    • 1
  • F. Tucci
    • 1
  • F. Mannelli
    • 2
  • M. E. Rossi
    • 1
  • C. Azzari
    • 1
  • A. Vierucci
    • 1
  1. 1.Department of PaediatricsUniversity of FlorenceFlorenceItaly
  2. 2.Division of Infectious DiseaseHospital A. MeyerFlorenceItaly

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