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A new rapid, regiospecific synthesis of 15-(p-[123I]iodophenyl)pentadecanoic acid

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Abstract

The triazene derivative of 15-(p-aminophenyl)pentadecanoic acid, 1-[4-(15-oxopentadecanoyl)phenyl]-3,3-(1,5-pentanediyl)triazene, has been sythesized as a new substrate which is readily converted to 15-(p-iodophenyl)-pentadecanoic acid (IPP). Iodine-123-labeled IPP is prepared in ∼30% yield in less than 30 min by reaction of the triazene with no-carrier added H123I, obtained by decay of123Xe. This rapid, regiospecific synthesis represents as improved method for the preparation of [123I]IPP.

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References

  1. H. J. MACHULLA, M. MARSMANN, K. DUTSCHKA, J. Radioanal. Chem., 56 (1980) 253.

    Google Scholar 

  2. H. J. MACHULLA, M. MARSMANN, K. DUTSCHKA, D. VANBEUNINGEN, Radiochem. Radioanal. Letters, 42 (1980) 243.

    Google Scholar 

  3. H. J. MACHULLA, M. MARSMANN, K. DUTSCHKA, Eur. J. Nucl. Med., 5 (1980) 171.

    PubMed  Google Scholar 

  4. P. F. ANGELBERGER, M. WANGER-LOFFLER, R. DUDCZAK, Second Intern. Symp. on Radiopharmacology, Chicago, IL, September 8–12, 1981, P 2 (abstract).

  5. R. DUDCZAK, R. SCHMOLINER, P. ANGELBERGER, Second Intern. Symp. on Radiopharmacology, Chicago, IL, September 8–12, 1981, P 23 (abstract).

  6. R. DUDCZAK, P. ANGELBERGER, M. WAGNER-LOFFLER, K. KLETTER, R. SCHMOLINER, H. FRISCHAUF, J. Nucl. Med., 22 (1981) 81 (abstract).

    Google Scholar 

  7. R. N. RESKE, H. J. MACHULLA, C. WINKLER, J. Nucl. Med., 23 (1982) 10 (abstract).

    Google Scholar 

  8. R. DUDCZAK, R. SCHMOLINER, P. ANGELBERGER, J. Nucl. Med., 23 (1982) 35 (abstract).

    Google Scholar 

  9. S. N. RESKE, H. SIMON, H. J. MACHULLA, H. J. BIERSACK, R. KNOPP, C. WINKLER, J. Nucl. Med., 23 (1982) 34 (abstract).

    PubMed  Google Scholar 

  10. S. N. RESKE, H. J. MACHULLA, H. J. BIERSACK, Second Intern. Symp. on Radiopharmacology, Chicago, IL, September 8–12, 1981 (abstract).

  11. S. N. RESKE, H. J. MACHULLA, H. L. BIERSACK, H. SIMON, R. KNOPP, C. WINKLER, In: Proc. Third World Congress of Nuclear Medicine and Biology, Paris, France, 1982, p. 106 (abstract).

  12. H. J. MACHULLA, T. CHEN, E. J. KNUST, K. DUTSCHKA, P. MEISSNER, E. SCHARFBORNHOFEN, G. BLUM, In: Third World Congress of Nuclear Medicine and Biology, Paris, France, 1982, p. 67 (abstract).

  13. P. RICHARDS, T. PRACH, S. C. SRIVASTAVA, J. Radioanal. Chem., 65 (1981) 47.

    Google Scholar 

  14. M. EISENHUT, Intern. J. Appl. Radiation Isotopes, 33 (1982) 499.

    Google Scholar 

  15. P. V. KULKARNI, R. W. PARKEY, J. Label. Comp. Radiopharm., 19 (1982) 1319.

    Google Scholar 

  16. M. M. GOODMAN, F. F. KNAPP, JR., J. Org. Chem., 47 (1982) 3004.

    Google Scholar 

  17. M. M. GOODMAN, F. F. KNAPP, JR. A. P. CALLAHAN, L. A. FERREN, J. Nucl. Med., 23 (1982) 904.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Nuclear Medicine Group, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee, (USA)

    M. M. Goodman & F. F. Knapp Jr.

  2. Medical Department, Brookhaven National Laboratory, Upton, New York, (USA)

    P. Richards & F. Mausner

Authors
  1. M. M. Goodman
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  2. F. F. Knapp Jr.
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  3. P. Richards
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  4. F. Mausner
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Additional information

Work supported by the Office of Health and Environmental Research (OHER), U. S. Department of Energy under contract W-7405-eng-26 with the Union Carbide Corporation at ORNL and under contract DE-AC0276CH0016 at BNL.

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Goodman, M.M., Knapp, F.F., Richards, P. et al. A new rapid, regiospecific synthesis of 15-(p-[123I]iodophenyl)pentadecanoic acid. Journal of Radioanalytical and Nuclear Chemistry, Articles 89, 63–70 (1985). https://doi.org/10.1007/BF02070204

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  • DOI: https://doi.org/10.1007/BF02070204

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