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Biochemical regulators in cardiac hypertrophy

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Summary

In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been shown to occur not only in the adrenal medulla but also in the adrenal cortex. Finally, detection of cross reactivity between digitalis glycosides and a number of steroid hormones has succeeded. We assume that such cross reactivity indicates the existence of an endogenic factor of steroid character, which is produced in the adrenal gland and functions as an endogenic cardiotonic agent. During experimental cardiac hypertrophy its synthesis is possibly increased.

We propose the term “endocardin” or “endocardiotonin” for this agent.

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References

  1. Aronson, J. K., A. R. Ford, D. G. Grahame-Smith: Techniques for studying the pharmacodynamic effect of cardiac glycosides on patients' own erythrocytes during glycoside therapy. Klin. Wochenschr.59, 1323–1332 (1982).

    Google Scholar 

  2. Beznak, M.: Hormonal influences in regulation of cardiac performance. Circulat. Res.14–15, Suppl. II, 141–162 (1964).

    Google Scholar 

  3. Bing, O. H. L., S. Matsushita, B. L. Fanburg, H. J. Levine: Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circulat. Res.28, 234–245 (1971).

    PubMed  Google Scholar 

  4. Bodemann, H. H.: Das Problem des zellulären Herzglycosidrezeptors. Klin. Wochenschr.59, 1333–1343 (1982).

    Google Scholar 

  5. Bugaisky, L., R. Zak: Cellular growth of cardiac muscle after birth. Texas Rep. Biol. Med.39, 123–138 (1979).

    Google Scholar 

  6. Caldarera, C. M., A. Casti, C. Rossoni, O. J. Visioli: Polyamines and noradrenaline following myocardial hypertrophy. J. Mol. Cell. Cardiol.3, 121–126 (1971).

    PubMed  Google Scholar 

  7. Caldarera, C. M., A. Casti, C. Guarnieri, G. Moruzzi: Polyamine and nucleoprotein correlations in hypertrophied and perfused heart. In: Rec. Adv. Stud. Struct. Metabol., vol. 7. pp. 91–97. Ed.: P. Harris, R. J. Bing, A. Fleckenstein, University Park Press (Baltimore 1976).

    Google Scholar 

  8. Caldarera, C. M., C. Guarnieri, C. Clô, R. Ferrari, A. Casti: Early biochemical events of myocardial hypertrophy. In: IIIème Réunion de la Section Européenne de l'International Society for Heart Research. pp. 125–138. Ed.: P. Padieu, J.-P. Didier (Dijon, France, 1979).

  9. Claycomb, W. C.: Culture of cardiac muscle cells in serum-free media. Exp. Cell Res.131, 231–236 (1980).

    Google Scholar 

  10. De Pover, A., G. Castaneda-Hernándes, T. Godfraind: Water versus acetone-HCl extraction of digitalis-like factor from guinea-pig heart. Biochem. Pharmacol.31, 267–271 (1982).

    PubMed  Google Scholar 

  11. Drost, R. H., Th. A. Plomp, A. J. Leunissen, A. H. J. Maas, R. A. A. Maes: A comparative study of the homogenous enzyme immunoassay (EMIT) and two radioimmunoassays (RIAs) for digoxin. Clin. chim. Acta79, 557–567 (1977).

    PubMed  Google Scholar 

  12. Fishman, M. C.: Endogenous digitalis-like activity in mammalian brain. Proc. Nat. Acad. Sci. U.S.76, 4661–4663 (1979).

    Google Scholar 

  13. Gibson, K., P. Harris: The effects of polyamines on cardiac protein biosynthesis. In: Rec. Adv. Stud. Card. Struct. Metabol., vol. 7. pp. 71–73. Ed.: P. Harris, R. J. Bing, A. Fleckenstein, University Park Press (Baltimore 1976).

    Google Scholar 

  14. Gibson, K., W. Krelhaus, P. Harris: Some properties of rat myocardial ornithine decarboxylase and the in vitro effects of nucleotides. In: Rec. Adv. Stud. Card. Struct. Metabol., vol. 7. pp. 77–83. Ed.: P. Harris, R. J. Bing, A. Fleckenstein, University Park Press (Baltimore 1976).

    Google Scholar 

  15. Gruber, K. A., J. M. Whitaker, V. M. Buckalew Jr.: Endogenous digitalis-like substance in plasma of volume-expanded dogs. Nature287, 743–745 (1980).

    PubMed  Google Scholar 

  16. Gruber, K. A., V. M. Buckalew Jr.: Evidence that natriuretic hormone is a cascading peptide hormone system. In: Hormonal regulation of sodium excretion. p. 349. Ed.: B. Lichardus, R. W. Schrier, J. Ponec. Elsevier-North Holland (Amsterdam 1980).

    Google Scholar 

  17. Gudbjarnason, S., H. Teleman, Ch. Chiba, P. Wolf, R. J. Bing: Myocardial protein synthesis in cardiac hypertrophy. J. Lab. Clin. Med.63, 245–253 (1964).

    Google Scholar 

  18. Hammond, C. L., E. Wieben, C. L. Markert: Molecular signals for initiating protein synthesis in organ hypertrophy. Proc. Nat. Acad. Sci. U.S.76, 2455–2459 (1979).

    Google Scholar 

  19. Hatt, P. Y., C. Ledoux, J. P. Bonvalet: Lyse et synthèse des protéines myocardique au cours de l'insuffisance cardiaque expérimentale. Arch. Mal. Cœur58, 1703–1721 (1965).

    Google Scholar 

  20. Haupert, C. T., J. M. Sancho: Sodium transport inhibitor from bovine hypothalamus. Proc. Nat. Acad. Sci. U.S.76, 4658–4660 (1979).

    Google Scholar 

  21. Heby, O., L. J. Marton, Ch. B. Wilson, H. M. Martinez: Polyamines: a high correlation with cell replication. Febs Letters50, 1–4 (1975).

    PubMed  Google Scholar 

  22. Heller, M., S. Beck, J. Friedman, H. Hallaq, M. Mersel, A. Pinson, H. Schwalb, E. Smith, E. Yehiel: Digitalis and the plasma membrane. In: IIIème Réunion de la Section Européenne de l'International Society for Heart Research, pp. 84–104. Ed.: P. Padieu, J.-P. Didier (Dijon 1979).

  23. Hood, W. P., Ch. E. Rackley, E. L. Rolett: Wall stress in the normal and hypertrophical human left ventricle. Amer. J. Cardiol.22, 550–558 (1968).

    PubMed  Google Scholar 

  24. Hort, W.: Morphologische und physiologische Untersuchungen an Ratten während eines Lauftrainings und nach dem Training. Virchows Arch.320, 197–237 (1951).

    PubMed  Google Scholar 

  25. Ishikawa, S., G. A. Fattal, Popiewicz, J. P. Wyatt: Functional morphometry of myocardial fibres in cor pulmonale. Amer. Rev. Respir. Dis.105, 358–367 (1972).

    Google Scholar 

  26. Kim, Ryung-soon, F. S. la Bella: Endogenous ligands and modulators of the digitalis receptor: some candidates. Pharmac. Ther.14, 391–409 (1981).

    Google Scholar 

  27. Kizu, A., K. Nakamura, M. Fujiwara, H. Okamori, I. Kimura, M. Yasumi, T. Minega, M. Tanaka, H. Ijichi: The role of hexose monophosphate pathway (HMP) in cardiac hypertrophy. J. Mol. Cell. Cardiol.13, Suppl. 2, 30 (1980).

    Google Scholar 

  28. Kölbel, F.: Protein synthesis in cardiac hypertrophy. Rev. Espagnol. Cardiol., Suppl.II: pp. 157–161 (1972).

    Google Scholar 

  29. Kölbel, F.: Metabolism of normal and hypertrophic right ventricle. In: Cor pulmonale chronicum. pp. 87–105. Ed.: S. Daum, Europ. Soc. Cardiol (Munich 1977).

    Google Scholar 

  30. Kölbel, F., J. Kapitola, O. Schreiberová, V. Kölbelová: Influence of adrenalectomy on the effects of isoproterenol in the rat. Physiol. Bohemosl.19, 281–285 (1970).

    Google Scholar 

  31. Kölbel, F., W. F. H. M. Mommaerts, V. Kölbelová, P. Vančura: Cardiac muscle and liver ribosomes of the rat: The influence of laparotomy and laparotomy combined with adrenalectomy. Experientia26, 361–362 (1970).

    Google Scholar 

  32. Kölbel, F., J. Kapitola, J. Šonka, O. Schreiberová: Hormonal and humoral modulation of the effect of isoproterenol. pp. 39–47. In: Les Surcharges Cardiaques, Colloque INSERM (Paris 1972).

  33. Kölbel, F., O. Schreiberová: Extracts of overloaded rats' hearts: their influence upon proteosynthesis of the myocardial tissue in vitro. p. 42. Adaptability of the cardiac muscle, Abstracts (Praha 1974).

  34. Kölbel, F., V. Dorazilová, L. Kümmel: Human heart aneurysm: Biochemical and morphological characteristics. In: Recent Advances in Studies on Cardiac Structure and Metabolism vol. 6. pp. 431–436. Ed.: A. Fleckenstein, G. Rona, Univ. Park Press (Baltimore 1975).

    Google Scholar 

  35. Kölbel, F., V. Schreiber, J. Štěpán, T. Přibyl, I. Gregorová: The endogenous digoxin-like substance endocardin (Abstract). J. Mollec. Cell. Cardiol.13, Suppl. 1, 45 (1981).

    Google Scholar 

  36. Kölbel, F., V. Schreiber, T. Přibyl: Reflection on what makes the heart grow. In: Advances in Myocardiology, vol. 4. Ed.: N. Dhalla, J. Chazov, Plenum Publ. Co (New York), 1982.

    Google Scholar 

  37. Kölbel, F., V. Schreiber, J. Štěpán, T. Přibyl, I. Gregorová: The endogenous digoxin-like substance-endocardin. In: Advances in Studies on Heart Metabolism, pp. 527–530. Ed.: C. M. Caldarera, P. Harris, CLUEB (Bologna 1982).

    Google Scholar 

  38. Krelhaus, W., K. Gibson, P. Harris: The effects of hypoxia, hypertrophy, and diet on rat myocardial ornithine decarboxylase activity. In: Rec. Adv. Stud. Card. Struct. Metabol. vol. 7. pp. 85–89. Ed.: P. Harris, R. I. Bing and A. Fleckenstein. University Park Press (Baltimore 1976).

    Google Scholar 

  39. Kyrge, P. K.: Myocardial sodium-potassium pump and its adrenocortical regulation as factors limiting cardiac adaptation to severe physical exertion. (Russian text). Kardiologija16, 15–21 (1976).

    Google Scholar 

  40. Lloyd, B. L., R. R. Taylor: Influence of myocardial mechanical activity and coronary blood flow on myocardial digoxin uptake. Cardiovasc. Res.4, 487–493 (1976).

    Google Scholar 

  41. Löwenstein, J. M., E. M. Corrill: An improved method for measuring plasma and tissue concentrations of digitalis glycosides. J. Lab. Clin. Med.67, 1048–1050 (1966).

    PubMed  Google Scholar 

  42. Meerson, F. Z.: Compensatory hyperfunction of the heart and cardiac insufficiency. Circulat. Res.10, 250–258 (1962).

    PubMed  Google Scholar 

  43. Meerson, F. Z.: Role of synthesis of nucleid acids and protein in adaptation to the external environment. Physiol. Rev.55, 79–123 (1975).

    PubMed  Google Scholar 

  44. Miller, T. B., J. H. Exton, C. H. Park: A bloc in epinephrine-induced glycogenolysis in hearts from adrenalectomized rats. J. Biol. Chem.246, 3672–3678 (1971).

    PubMed  Google Scholar 

  45. Mori, K. J., H. Izumi, A. Seto: Stimulation and support of haemopoietic stem cell proliferation by irradiated stroma cell colonies in bone marrow culturein vitro. J. Radiat. Res.22, 109–115 (1981).

    PubMed  Google Scholar 

  46. Norman, T. D.: The pathogenesis of cardiac hypertrophy. Progr. Cardiovascul. Dis.4, 439–463 (1962).

    Google Scholar 

  47. Onji, T., M.-S. Liu: Ouabain in isolated adult dog heart myocytes. Arch. Biochem. Biophys.207, 148–156 (1981).

    PubMed  Google Scholar 

  48. Pegg, A. E.: Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy. J. Mol. Cell. Cardiol.13, 881–887 (1981).

    PubMed  Google Scholar 

  49. Rabinowitz, M., R. Zak: Biochemical and cellular changes in cardiac hypertrophy. Amer. Rev. Med.23, 245–262 (1972).

    Google Scholar 

  50. Rifka, S. M., J. C. Pita Jr., D. L. Loriaux: Mechanism of interaction of digitalis with estradiol binding sites in rat uteri. Endocrinology99, 1091–1096 (1976).

    PubMed  Google Scholar 

  51. Ross, J. S., N. L. R. Bucher, R. A. Malt: Compensatory renal hypertrophy in eviscerated rats. Cancer Res.34, 502–505 (1974).

    PubMed  Google Scholar 

  52. Sanguansermsri, J., P. György, F. Zilliken: Polyamines in human and cows' milk. Amer. J. Clin. Nutr.27, 859–865 (1974).

    PubMed  Google Scholar 

  53. Schrader, W. T., J. M. Seleznev, W. V. Vedeckis, B. W. O'Malley: Steroid receptor subunit structure. In: Gene regulation by steroid hormones. pp. 77–88. Springer-Verlag (New York 1979).

    Google Scholar 

  54. Schreiber, S. S., M. Oratz, M. A. Rothschild, F. Reff: Effect of hydrostatic pressure on isolated cardiac nuclei: Stimulation of RNA polymerase II activity. Cardiovasc. Res.12, 265–268 (1978).

    PubMed  Google Scholar 

  55. Schreiber, V.: Neuropeptides and neurosteroids. (Czech text) Čas. lék. čes.119, 656–659 (1980).

    Google Scholar 

  56. Schreiber, V., F. Kölbel, J. Štěpán: Apparent(?) immunoreactivity of digoxin in the sera of rats with cardiac overload — on the problem of endogenous cardiotonic (Endocardin). (Czech text) Čas. lék. čes.119, 768–770 (1980).

    Google Scholar 

  57. Schreiber, V., J. Štěpán, I. Gregorová, F. Kölbel, T. Přibyl, J. Jahodová, V. Janovská: Digoxin-like immunoreactivity in serum of hyperthyroid rats with hypertrophy of the heart is not caused by aldosterone. (Czech text) Sborn. lék.82, 305–308 (1980).

    Google Scholar 

  58. Schreiber, V., J. Štěpán, F. Kölbel, T. Přibyl, J. Jahodová, V. Kubová: Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by “apparent” digoxin immunoreactivity in the blood. Physiol. bohemoslov.29, 577–579 (1980).

    PubMed  Google Scholar 

  59. Schreiber, V., I. Gregorová, T. Přibyl, J. Štěpán: Digitalis-like biological activity and immunoreactivity in chromatographic fractions of rabbit adrenal extract. Endocr. experiment.15, 229–236 (1981).

    Google Scholar 

  60. Schreiber, V., F. Kölbel, J. Štěpán, I. Gregorová, T. Přibyl: Digoxin-like immunoreactivity in the serum of rat with cardiac overload. J. Molec. Cell. Cardiol.13, 107–110 (1981).

    Google Scholar 

  61. Schreiber, V., F. Kölbel, J. Štěpán, T. Přibyl, J. Jahodová, V. Kubová: Correlations between adrenal weight and heart weight in rats with a cardiac overload. Physiol. bohemoslov.30, 289–294 (1981).

    PubMed  Google Scholar 

  62. Schreiber, V., J. Štěpán, T. Přibyl, L. Stárka: Digitalis glycoside-like biological activity (inhibition of86Rb+ uptake by red blood cells in vitro) of certain steroids and other hormones. Biochem. Pharmac.30, 3001–3002 (1981).

    Google Scholar 

  63. Schreiber, V., F. Kölbel, T. Přibyl, J. Jahodová, V. Kubová: Aminoglutethimide, an inhibitor of adrenal steroidogenesis, blocks heart growth after ligation of the abdominal aorta, and in hyperthyroidism. Phys. bohemoslov.31, 497–502 (1982).

    Google Scholar 

  64. Seleznev, J. M., S. M. Danilov, V. N. Smirnov: Separation of three glucocorticoid-binding fractions from cytosol of rat heart. J. Steroid. Biochem.10, 215–220 (1979).

    PubMed  Google Scholar 

  65. Seleznev, J. M., S. M. Danilov, N. G. Volkova, G. V. Kolpakova: Glucocorticoids in the hormonal regulation of cardiac metabolism. pp. 243–259. In: Proceedings of the 4th USA-USSR Joint Symposium on Myocardial Metabolism, September 14–16, 1979.

  66. Stoffer, S. S., K. M. Hynes, Nai Siang Jiang, R. J. Ryan: Digoxin and abnormal serum hormone levels. J. Amer. Med. Ass.225, 1643–1645 (1973).

    Google Scholar 

  67. Tanaka, M., H. Yamada, T. Matsuvra, K. Fukui, T. Kuribayashi, H. Katsume, A. Kizu, H. Ijichi, Y. Ibata: Morphological study of cardiac hypertrophy induced by cold stress in rats. J. Mol. Cell. Cardiol.13, Suppl. 2, 42 (1981).

    Google Scholar 

  68. Turto, H., S. Lindy: Digitoxin treatment and experimental cardiac hypertrophy in the rat. Cardiovasc. Res.7, 482–489 (1973).

    PubMed  Google Scholar 

  69. Van Urk, H., D. Malamud, L. Soler-Montesinos, R. A. Malt: Compensatory hyperplasia with increasing loss of renal mass. Laborat. Invest.38, 674–676 (1978).

    PubMed  Google Scholar 

  70. Vandenburgh, H., S. Kaufman: In vitro model for stretch-induced hypertrophy of skeletal muscle. Science203, 265–268 (1979).

    PubMed  Google Scholar 

  71. Van Vroonhoven, T. J., L. Soler-Montesinos, R. A. Malt: Humoral regulation of renal mass. Surgery72, 300–305 (1972).

    PubMed  Google Scholar 

  72. Wachtlová, M., V. Mareš, B. Oštádal: DNA synthesis in the ventricular myocardium of young rats exposed to intermittent high altitude hypoxia (IHA). An autoradiographic study. Virchows Arch. B. Cell. Path.24, 335–342 (1977).

    Google Scholar 

  73. Zak, R., D. A. Fischman: Studies on protein synthesis in heart muscle during development and in experimentally produced hypertrophy. In: Cardiac hypertrophy, pp. 247–257. Ed.: N. Alpert, Acad. Press (New York 1971).

    Google Scholar 

  74. Zimmer, H. G., E. Gerlach: Early metabolic alterations during the development of experimentally induced cardiac hypertrophy. Drug Res.30, 2001–2007 (1980).

    Google Scholar 

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  1. F. Kölbel

    Present address: Third Medical Department, Faculty of Medicine, Charles University, U nemocnice 1, 128 21, Prague 2, Czechoslovakia

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  1. Third Medical Department, Faculty of Medicine, Charles University, U nemocnice 1, 128 21, Prague 2, Czechoslovakia

    V. Schreiber

  2. Laboratory for Endocrinology and Metabolism, Faculty of Medicine, Charles University, U nemocnice 1, 128 21, Prague 2, Czechoslovakia

    F. Kölbel & V. Schreiber

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Kölbel, F., Schreiber, V. Biochemical regulators in cardiac hypertrophy. Basic Res Cardiol 78, 351–363 (1983). https://doi.org/10.1007/BF02070160

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