Bulletin of Experimental Biology and Medicine

, Volume 70, Issue 6, pp 1365–1367 | Cite as

Deafferentation anemia in splenectomized animals

  • M. I. Pekarskii
Pathological Physiology And General Pathology


Experiments on cats have shown that the reaction of the blood and bone marrow to division of the brachial plexus is the same in intact and splenectomized animals. This reaction consists of the development of anemia and neutrophilic leukocytosis, as the result of myeloid metaplasia of the bone marrow, which regularly develops in response to a focus of deafferentation in the body. The changes described are fully developed 3–4 weeks after denervation. They are uniform in character and show no tendency toward normalization throughout the period of observation (until 6 months after denervation). The experiments also show that the spleen does not play a leading role in the mechanism of development of this type of anemia.


Bone Marrow Internal Medicine Anemia Brachial Plexus Myeloid Metaplasia 
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Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • M. I. Pekarskii
    • 1
  1. 1.Department of Embryology and Age HistologyN. I. Pirogov Second Moscow Medical InstituteUSSR

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