Journal of Assisted Reproduction and Genetics

, Volume 13, Issue 3, pp 254–258 | Cite as

Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease: Biochemical and ultrasonic studies in the first trimester of pregnancy

  • Iakovos Soussis
  • Joyce C. Harper
  • Elena Kontogianni
  • Thanos Paraschos
  • Dina Packham
  • Alan H. Handyside
  • Robert M. L. Winston


Purpose: Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease.

Results: Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies.

Conclusions: Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy.

Key words

preimplantation diagnosis embryo biopsy in vitro fertilization pregnancies biochemical measurements human chorionic gonadotropin progesterone ultrasound measurements 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Iakovos Soussis
    • 2
  • Joyce C. Harper
    • 2
    • 1
  • Elena Kontogianni
    • 2
  • Thanos Paraschos
    • 2
  • Dina Packham
    • 2
  • Alan H. Handyside
    • 2
  • Robert M. L. Winston
    • 2
  1. 1.Department of Genetics and Biometry, Galton LaboratoryUniversity College LondonLondonUK
  2. 2.PRMS, Hammersmith HospitalInstitute of Obstetrics & GynaecologyLondonUK

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