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Fundic argyrophil carcinoid tumor in a patient with sporadic-type zollinger-ellison syndrome

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Summary

In the Zollinger-Ellison syndrome, fundic argyrophil carcinoid tumors occur almost exclusively in the small subgroup of patients who also have multiple endocrine neoplasia type 1. In these patients, tumor development seems related to the same genetic alterations as those observed in other endocrine tumors related to multiple endocrine neoplasia type 1. We report here the second detailed case of a patient with sporadic Zollinger-Ellison syndrome who developed an argyrophil carcinoid tumor in nonatrophic fundic mucosa, suggesting that chronic hypergastrinemia may lead to fundic carcinoid development in non-genetically predisposed patients.

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Authors and Affiliations

  1. From the Departments of Gastroenterology and Pathology, Bichat-Claude Bernard Hospital, 46 rue Henri Huchard, 75877, Paris Cedex 18, France

    Guillaume Cadiot MD, Christiane Vissuzaine MD, François Potet MD & Michel Mignon MD

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  1. Guillaume Cadiot MD
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  2. Christiane Vissuzaine MD
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  3. François Potet MD
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  4. Michel Mignon MD
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Cadiot, G., Vissuzaine, C., Potet, F. et al. Fundic argyrophil carcinoid tumor in a patient with sporadic-type zollinger-ellison syndrome. Digest Dis Sci 40, 1275–1278 (1995). https://doi.org/10.1007/BF02065537

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  • DOI: https://doi.org/10.1007/BF02065537

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