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Gastric juice ammonia vs CLO test for diagnosis ofHelicobacter pylori infection

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

The aim of the present study was to compare the gastric juice ammonia test to the CLO test for the diagnosis ofH. pylori infection in culture-proven cases by receiver operating characteristic (ROC) curve analysis. We studied 75 subjects (44 with chronic gastritis, 10 with gastric ulcer, 6 with duodenal ulcer, 8 with gastric cancer, and 7 normal) by endoscopy with biopsy for tissue diagnosis, culture ofH. pylori. CLO test, and by gastric juice ammonia determinations. The culture-positive group had significantly higher intragastric ammonia levels (13.7±5.8 mg/dl) than the negative group (4.9±2.4 mg/dl,P<0.01). In ROC curve analysis, the gastric juice ammonia test showed higher true positive and lower false positive ratios than the CLO test (P<0.05). In conclusion, the measurement of intragastric juice ammonia levels was considered to be simpler, quicker, and overall a more valuable method for diagnosingH. pylori infection.

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Authors and Affiliations

  1. From the Department of Internal Medicine, Chonnam University, Medical School, Kwangju, Korea

    Dae Hyun Yang MD, Hee Seung Bom MD, Young Eun Joo MD, Sung Kyu Choi MD, Jong Sun Rew MD &  Chong Mann Yoon MD

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  1. Dae Hyun Yang MD
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  2. Hee Seung Bom MD
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  3. Young Eun Joo MD
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  4. Sung Kyu Choi MD
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  5. Jong Sun Rew MD
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  6. Chong Mann Yoon MD
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Yang, D.H., Bom, H.S., Joo, Y.E. et al. Gastric juice ammonia vs CLO test for diagnosis ofHelicobacter pylori infection. Digest Dis Sci 40, 1083–1086 (1995). https://doi.org/10.1007/BF02064203

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  • DOI: https://doi.org/10.1007/BF02064203

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