Abstract
We compared the filling responses of the cecum and the sigmoid of the guinea pig using volumes up to 60 ml and 2.5 ml, respectively. In the isolated cecum, each 1-cm increment of hydrostatic pressure above zero led to accommodation of 10 ml volume; in the sigmoid, the yield pressure (at which accommodation first occurred) was 6 cm H2O, and pressure increments up to 20 cm H2O produced volume increments of less than 0.5 ml. Resting pressure at half-maximal filling was 5.0±0.7 cm H2O for the sigmoid and 1.7±0.6 cm H2O for the cecum. K+ depolarization led to a significant upward shift in the pressure curves of both segments. Ca2+ withdrawal decreased sigmoid and cecal pressures at some volumes. Distension of the cecum triggered intermittent contractions, which began with the shortening of the teniae and were associated with low-amplitude pressures and expulsion of a 5- to 10-ml volume. Distension of the sigmoid produced propagating contractions that were associated with high-amplitude pressures and lengthening; compartmentalization in the sigmoid prevented efflux from it, and volume inflow was not affected by pressure waves. Our observations indicate that its large capacity and great distensibility make the cecum suitable for reservoir functions, whereas its narrowness and lack of distensibility make the sigmoid a high-resistance conduit.
Similar content being viewed by others
References
Schulze-Delrieu K, Wall JP: Mechanical activity of muscular patch pouches from cat and rabbit stomachs. Gastroenterology 88:1012–1019, 1985
Schulze-Delrieu K, Shirazi SS: Pressure and length adaptations in the isolated cat stomach. Am J Physiol 15:G92-G99, 1987
Christensen J: Motility of the colon.In Physiology of the Gastrointestinal Tract, Vol 2, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 665–693
Ehrlein HJ, Reich H, Schwinger M: Colonic motility and transit of digesta during hard and soft feces formation in rabbits. J Physiol 338:75–86, 1983
Huizinga JD, Daniel EE: Motor functions of the colon.In The Large Intestine: Physiology, Pathophysiology and Disease. SF Phillips, JH Pemberton, RG Shorter (eds). New York, Raven Press, 1991
Weems WA, Weisbrodt NW: Ileal and colonic propulsive behavior: Contribution of enteric neural circuits. Am J Physiol 250:G653-G659, 1986
Elliott TR, Barclay-Smith E: Antiperistalsis and other muscular activities of the colon. J Physiol 31:272–304, 1904
Ritchie JA: Colonic motor activity and bowel function. I. Normal movement of contents. Gut 9:442–456, 1968
Sarna SK: Physiology and pathophysiology of colonic motor activity. Part Two. Dig Dis Sci 36:998–1018, 1991
Gabella G: On the musculature of the gastrointestinal tract of the guinea-pig. Anat Embryol 163:135–156, 1981
Tucker HJ, Snape WJ Jr, Cohen S: Comparison of proximal and distal colonic muscle of the rabbit. Am J Physiol 237:E383–388, 1979
Snape WJ Jr, Kim BH, Willenbucher R, Koelbel C, Mayer EA, Walsh JH: The response of proximal and distal rabbit colonic muscle after electrical field stimulation. Gastroenterology 96:321–326, 1989
Snape WJ Jr, Mayer EA, Koelbel CBM, Hyman PE, Williams R: Different response of smooth muscle from different regions of the human colon. J Gastrointest Motil 1:29–34, 1989
Snape WJ Jr, Crawford B, Hyman PE, Lechago J: Anatomic contribution to differences in rabbit colonic muscle contraction. Gastroenterology 100:75–81, 1991
Kerlin P, Zinsmeister A, Phillips S: Motor responses to food of the ileum, proximal colon and distal colon of healthy humans. Gastroenterology 84:762–770, 1983
Schulze-Delrieu K: Clearance Patterns of the isolated guinea pig duodenum. Gastroenterology 102:849–856, 1992
Custer-Hagen T, Schulze-Delrieu K: Movement of haustra and of particles in the isolated guinea pig cecum. Clin Res 37:366A, 1989
Wade PR, Wood JD: Electrical behavior of myenteric neurons in guinea pig distal colon. Am J Physiol 254:G522-G530, 1988
Neri M, Phillips S, Fich A: Measurement of tone in canine colon. Am J Physiol 260:G505-G511, 1991
Steadman ChJ, Phillips SF, Camilleri M, Haddad AC, Hanson RB: Variation of muscle tone in the human colon. Gastroenterology 101:373–381, 1991
Waldron DJ, Gill RC, Bowes KL: Pressure response of the human colon to intraluminal distension. Dig Dis Sci 34:1163–1167, 1989
Moreno-Osset E, Bazzochi G, Lo S, Trombley B, Ristow E, Reddy SN, Villaneueva-Meyer J, Fain JW, Jing J, Merian I, Snape WJ: Association between postprandial changes in colonic intraluminal pressure and transit. Gastroenterology 96:1265–1273, 1989
Krevsky B, Malmud LS, D'Ercole F, Maurer AH, Fischer RS: Colonic transit scintigraphy. A physiologic approach to the quantitative measurement of colonic transit in humans. Gastroenterology 91:1102–1112, 1986
Proano M, Camilleri M, Phillips SF, Brown ML, Thomforde GM: Transit of solids through the human colon: Regional quantification in the unprepared bowel. Am J Physiol 258:G856-G862, 1990
Costa M, Furness JB: The peristaltic reflex: An analysis of the nerve pathways and their pharmacology. Naunyn-Schmiedeberg's Arch Pharmacol 294:47–60, 1976
Crema A, Frigo GM, Lecchini S: A pharmacological analysis of the peristaltic reflex in the isolated colon of the guinea-pig or cat. Br J Pharmacol 39:334–345, 1970
Liu HS, Karakida T, Homma S:In vitro motor activity and compliance of the caecum in streptozotocin diabetic rats. Jpn J Physiol 40:843–851, 1990
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lange, W., Schulze-Delrieu, K., Lange, H. et al. Cecum of guinea pig is a reservoir and sigmoid is a high-resistance conduit. Digest Dis Sci 40, 1015–1023 (1995). https://doi.org/10.1007/BF02064191
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02064191