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Effect of plaunotol on hypergastrinemia induced by long-term omeprazole administration in humans

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

Omeprazole markedly inhibits basal and stimulated gastric acid secretion and has the ability to produce hypergastrinemia and hyperplasia of enterochromaffin-like cells in humans. On the other hand, paunotol, an acyclic diterpene alcohol, has been reported to inhibit gastrin release by stimulating endogenous secretin release. We investigated the effect of plaunotol on serum gastrin levels after six to eight weeks of omeprazole (20 mg/day) administration in 22 patients (16 males, 6 females; mean age 52.3, range 36–70 years) with peptic ulcer disease. The patients were randomized to the following two groups: 11 subjects with omerprazole alone (single group) and 11 with omeprazole plus plaunotol (240 mg/day) (combination group) treatment. There were no significant differences between the two groups concerning age, sex, ulcer stage, ulcer history, environmental factors, andHelicobacter pylori (HP) prevalence. After complete drug(s) administration, serum immunoreactive (ir) -gastrin levels increased significantly in the single group (P<0.001) in contrast to the combination group, and plaunotol significantly inhibited hypergastrinemia induced by omeprazole administration (P<0.001). Significant increases in serum ir-calcitonin gene-related peptide concentrations were observed in the combination group compared to the single group (P<0.05). However, there were no significant changes in serum ir-secretin, somatostatin, and vasoactive intestinal polypeptide levels as well as ulcer healing and HP prevalence between the two groups. These findings suggest that plaunotol may suppress hypergastrinemia induced by long-term omeprazole administration, at least partly, via a certain brain-gut hormone affecting gastrin release.

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Authors and Affiliations

  1. First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan

    Hiroshi Kandeko MD, Terunori Mitsuma MD, Hirofumi Nagai MD, Masatoshi Harada MD, Hiroshi Kotera MD, Atsushi Furusawa MD & Kimitomo Morise MD

  2. Fourth Department of Internal Medicine, Aichi Medical University, 21 Karimata, Yazoko, Nagakute-cho, Aichi-gun, 480-11, Aichi-ken, Japan

    Hiroshi Kandeko MD, Terunori Mitsuma MD, Hirofumi Nagai MD, Masatoshi Harada MD, Hiroshi Kotera MD, Atsushi Furusawa MD & Kimitomo Morise MD

Authors
  1. Hiroshi Kandeko MD
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  2. Terunori Mitsuma MD
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  3. Hirofumi Nagai MD
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  4. Masatoshi Harada MD
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  5. Hiroshi Kotera MD
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  6. Atsushi Furusawa MD
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  7. Kimitomo Morise MD
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Kandeko, H., Mitsuma, T., Nagai, H. et al. Effect of plaunotol on hypergastrinemia induced by long-term omeprazole administration in humans. Digest Dis Sci 40, 160–165 (1995). https://doi.org/10.1007/BF02063960

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  • DOI: https://doi.org/10.1007/BF02063960

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