Digestive Diseases and Sciences

, Volume 40, Issue 1, pp 153–159 | Cite as

Helicobacter pylori infection

A reversible cause of hypergastrinemia and hyperchlorhydria which may mimic Zollinger-Ellison syndrome
  • David C. Metz
  • H. Christian Weber
  • Murray Orbuch
  • Doris B. Strader
  • Irina A. Lubensky
  • Robert T. Jensen
Case Report

Summary

The present report describes two patients with fasting hypergastrinemia, gastric acid hypersecretion, andHelicobacter pylori gastritis. Provocative testing for Zollinger-Ellison syndrome was negative and imaging studies did not demonstrate an intra-abdominal mass. Following eradication of theHelicobacter pylori infection, the fasting hypergastrinemia resolved in both patients and in one patient the gastric acid hypersecretion also resolved. The implications of this case on the differential diagnosis of Zollinger-Ellison syndrome are discussed.

Key words

gastric acid hypersecretion duodenal ulcer stomach gastrinoma Zollinger-Ellison syndrome 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • David C. Metz
    • 1
    • 2
  • H. Christian Weber
    • 1
    • 2
  • Murray Orbuch
    • 1
    • 2
  • Doris B. Strader
    • 1
    • 2
  • Irina A. Lubensky
    • 1
    • 2
  • Robert T. Jensen
    • 1
    • 2
  1. 1.From the Digestive Diseases BranchNational Institute of Diabetes and Digestive and Kidney DiseasesUSA
  2. 2.Laboratory of PathologyNational Cancer Institute, National Institutes of HealthBethesda

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