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Carcinomas of the colon with multidirectional differentiation

Report of two cases and review of the literature

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Summary

Two cases of colonic carcinomas with multidirectional differentiation are presented. Both tumors showed light microscopic and immunohistochemical evidence of areas of adenocarcinomatous, squamous cell carcinomatous, and neuroendocrine differentiation. Only six similar cases have been previously reported. These highly malignant tumors support the recent concept of a multipotential stem cell within the mucosa of the gastrointestinal tract capable of differentiation in several directions.

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Authors and Affiliations

  1. From the Departments of Gastroenterology, Pathology, and Surgery, Institut Gustave-Roussy, 94800, Villejuif, France

    Pierre Novello MD, Pierre Duvillard MD, Sophie Grandjouan MD, Dominique Elias MD, Philippe Rougier MD, Caroline Bognel MD & Michel Prade MD

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  1. Pierre Novello MD
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  2. Pierre Duvillard MD
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  3. Sophie Grandjouan MD
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  4. Dominique Elias MD
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  5. Philippe Rougier MD
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  6. Caroline Bognel MD
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  7. Michel Prade MD
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Novello, P., Duvillard, P., Grandjouan, S. et al. Carcinomas of the colon with multidirectional differentiation. Digest Dis Sci 40, 100–106 (1995). https://doi.org/10.1007/BF02063950

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  • DOI: https://doi.org/10.1007/BF02063950

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