Effect of capsaicin on release of substance P-like immunoreactivity from vascularly perfused rat duodenum
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The release of substance P-like immunoreactivity (SPLI) from the rat duodenum was investigated using anin situ vascularly perfused preparation. Results show that the basal release of SPLI was measurable and significantly enhanced by the administration of both 1, 3, and 10 µM of capsaicin, indicating that SPLI is present in capsaicin-sensitive afferent nerve fibers. It is concluded that the present model may be useful for the study of the control of duodenal release of SPLI.
Key wordsrat duodenum substance P-like immunoreactivity capsaicin
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