Digestive Diseases and Sciences

, Volume 40, Issue 1, pp 21–27 | Cite as

Serum carboxy terminal propeptide of type I procollagen to amino terminal propeptide of type III procollagen ratio is a better indicator than each single propeptide and 7S domain type IV collagen for progressive fibrogenesis in chronic viral liver diseases

  • D. Y. Lin
  • C. M. CHU
  • I. S. Sheen
  • Y. F. Liaw
Liver: Infectious, Inflammatory, And Metabolic Disorders


Twenty chronic viral hepatitis patients, mainly with hepatitis B related with progression to liver cirrhosis were included for an assay of serum collagen markers: PICP (carboxy terminal propeptide of type I procollagen), PIIINP (amino terminal propeptide of type III procollagen), and 7S-IV (7S-domain type IV collagen). PICP is increased in 20% of chronic hepatitis patients with a mean of 190.3 ng/ml, which is not different from that of the follow-up concentration in liver cirrhosis, where 35% of cases were abnormal with a mean of 220.5 ng/ml. The serum level and percent of abnormality of PIIICP in chronic hepatitis and in liver cirrhosis are 23.5 ng/ml vs 14.8 ng/ml and 90% vs 100%, respectively (P>0.05). PICP/PIIINP is significantly higher during liver cirrhosis (15.11 vs 10.08,P<0.05). PICP during chronic hepatitis is not related to serum biochemical changes, while PICP during liver cirrhosis and PIIINP are correlated with hepatic enzymes. 7S-IV in chronic hepatitis and in liver cirrhosis is 14.0 ng/ml vs 10.9 ng/ml, respectively; both were positively correlated with hepatic enzymes. These results suggest that PICP/PIIINP is a better indicator of hepatic fibrogenesis than either PICP or PIIINP alone in viral hepatitis. A ratio of more than 12 is suggestive of liver cirrhosis.

Key words

hepatic fibrosis PICP PIIINP 7S-IV collagen viral hepatitis 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • D. Y. Lin
    • 1
  • C. M. CHU
    • 1
  • I. S. Sheen
    • 1
  • Y. F. Liaw
    • 1
  1. 1.From the Liver UnitChang Gung Memorial Hospital and Chang Gung Medical College TaipeiTaiwan

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