Advertisement

Digestive Diseases and Sciences

, Volume 40, Issue 1, pp 21–27 | Cite as

Serum carboxy terminal propeptide of type I procollagen to amino terminal propeptide of type III procollagen ratio is a better indicator than each single propeptide and 7S domain type IV collagen for progressive fibrogenesis in chronic viral liver diseases

  • D. Y. Lin
  • C. M. CHU
  • I. S. Sheen
  • Y. F. Liaw
Liver: Infectious, Inflammatory, And Metabolic Disorders

Abstract

Twenty chronic viral hepatitis patients, mainly with hepatitis B related with progression to liver cirrhosis were included for an assay of serum collagen markers: PICP (carboxy terminal propeptide of type I procollagen), PIIINP (amino terminal propeptide of type III procollagen), and 7S-IV (7S-domain type IV collagen). PICP is increased in 20% of chronic hepatitis patients with a mean of 190.3 ng/ml, which is not different from that of the follow-up concentration in liver cirrhosis, where 35% of cases were abnormal with a mean of 220.5 ng/ml. The serum level and percent of abnormality of PIIICP in chronic hepatitis and in liver cirrhosis are 23.5 ng/ml vs 14.8 ng/ml and 90% vs 100%, respectively (P>0.05). PICP/PIIINP is significantly higher during liver cirrhosis (15.11 vs 10.08,P<0.05). PICP during chronic hepatitis is not related to serum biochemical changes, while PICP during liver cirrhosis and PIIINP are correlated with hepatic enzymes. 7S-IV in chronic hepatitis and in liver cirrhosis is 14.0 ng/ml vs 10.9 ng/ml, respectively; both were positively correlated with hepatic enzymes. These results suggest that PICP/PIIINP is a better indicator of hepatic fibrogenesis than either PICP or PIIINP alone in viral hepatitis. A ratio of more than 12 is suggestive of liver cirrhosis.

Key words

hepatic fibrosis PICP PIIINP 7S-IV collagen viral hepatitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lin DY, Sheen IS, Chiu CT, Lin SM, Kuo YC, Liaw YF: Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B—a longitudinal study. J Clin Ultrasound 21:303–308, 1993PubMedGoogle Scholar
  2. 2.
    Okuda K: Imaging methods.In Liver Cirrhosis. JL Boyer, L Bianchi (eds). Lancaster, MTP Press, 1987, pp 213–275Google Scholar
  3. 3.
    Lee CM, Liaw YF, Huang MJ, Chen TJ, Chu CM, Sheen IS, Lin HH: Serum level ofN-terminal peptide of procollagen type III in chronic liver disease. J Formosan Med Assoc 86:769–773, 1987Google Scholar
  4. 4.
    Colombo M, Annoni G, Donato MF, Martines D, Zaramella MG, Bianchi PA, Piperno A, Tiribelli C: Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis: its relationship to hepatic fibrosis, activity of the disease and iron overload. Hepatology 5:475–479, 1985PubMedGoogle Scholar
  5. 5.
    Risteli L, Risteli J: Analysis of extracellular matrix protein in biological fluids. Methods Enzymol 145:391–411, 1987PubMedGoogle Scholar
  6. 6.
    Bell H, Raknerud N, Orjaseter H, Huag E: Serum procollagen III peptide in alcoholic and other chronic liver disease. Scand J Gastroenterol 24:1217–1222, 1989PubMedGoogle Scholar
  7. 7.
    Eriksson S, Zettervall O: TheN-terminal propeptide of collagen type III in serum as a prognostic indicator of primary biliary cirrhosis. J Hepatol 2:370–378, 1986PubMedGoogle Scholar
  8. 8.
    Weigand K, Zaugg P-Y, Frei A, Zimmermann A: Long term follow up of theN-terminal propeptide of collagen type III in serum of patients with chronic liver disease. Hepatology 4:835–838, 1984PubMedGoogle Scholar
  9. 9.
    Annoni G, Colombo M, Cantaluppi MC, Khlat B, Lampertico P, Rojkind M: Serum type III prollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcoholic abusess. Hepatology 9:693–697, 1989PubMedGoogle Scholar
  10. 10.
    Shahin M, Schuppan D, Waldherr R, Risteli J, Risteli L. Savolainen ER, Oesterling C, Rahman HMA, Sahly ME, Razek SMA, Ruby OE, Koch A, Seitz HK: Serum procollagen peptides and collagen type VI for the assessment of activity and degree of hepatic fibrosis in schistosomiasis and alcoholic liver disease. Hepatology 15:637–644, 1992PubMedGoogle Scholar
  11. 11.
    Pott G, Rauterberg J, Voss B, Gerlach U: Connective tissue components of the normal and fibrotic human liver II. clinical aspects. Klin Wochenschr 60:1–7, 1982PubMedGoogle Scholar
  12. 12.
    Niemela O, Risteli L, Sotaniemi A, Risteli J. Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease. Eur J Clin Invest 15:132–137, 1985PubMedGoogle Scholar
  13. 13.
    Rojkind M: The blue glass and the predictive value of serum amino-terminal propeptide of type III procollagen as a marker of liver disease. Hepatology 4:977–978, 1984PubMedGoogle Scholar
  14. 14.
    Burgeson RE: New collagens, new concepts. Annu Rev Cell Biol 4:551–577, 1988PubMedGoogle Scholar
  15. 15.
    Melkko J, Niemi S, Risteli L, Risteli J: Radioimmunoassay for the carboxyterminal propeptide of human type I procollagen (PICP). Clin Chem 367:1328–1332, 1990Google Scholar
  16. 16.
    Rauterbery J, Voss B, Pott G, Gerlach U: Connective tissue components of the normal and fibrotic liver I. Structure, local distribution and metabolism of connective tissue components in the normal liver and changes in chronic liver disease. Klin Wochenschr 59:767–779, 1981PubMedGoogle Scholar
  17. 17.
    Savolainen ER, Goldberg B, Leo MA, Velez M, Lieber CS: Diagnostic value of serum procollagen peptide measurements in alcoholic liver disease. Alcohol Clin Exp Res 8:384–389, 1984PubMedGoogle Scholar
  18. 18.
    Schuppan D: Structure of the extracellular matrix in normal and fibrotic liver: Collagens and glycoproteins. Semin Liver Dis 10:1–10, 1990PubMedGoogle Scholar
  19. 19.
    Bentsen KD, Horslev-Petersen K, Junker P, Juhl E, Lorenzen I. The Copenhagen hepatitis acuta programme: Serum aminoterminal procollagen type III peptide in acute viral hepatitis—a long term follow-up study. Liver 7:96–105, 1987PubMedGoogle Scholar
  20. 20.
    Trivedi P, Risteli K, Risteli L, Tanner S, Bhave S, Pandit AN, Mowat AP. Serum type III procollagen and basement membrane proteins as noninvasive markers of hepatic pathology in Indian childhood cirrhosis. Hepatology 7:1249–1253, 1987PubMedGoogle Scholar
  21. 21.
    Igarashi S, Funaki N, Hatahara T, Inoue T: Clinical significance of the assay of 7S and type IV collagen in the sera with various liver disease—comparison with PIIIP and laminin P1 concentrations. Acta Hepatol Jpn 31:524–530, 1990 (in Japanese)Google Scholar
  22. 22.
    Misaki M, Shima T, Yano Y, Sumita Y, Kano U, Murata T, Watanabe S, Suzuki S: Basement membrane-related and type III procollagen-related antigens in serum of patients with viral liver disease. Clin Chem 36:522–524, 1990PubMedGoogle Scholar
  23. 23.
    Schlichting P, Fauerholdt L, Christensen E, Poulsen H, Juhl E, Tygstrup N: The Copenhagen Study Group For Liver Disease. Clinical relevance of restrictive morphological criteria for the diagnosis of cirrhosis in liver biopsy. Liver 1:56–61, 1981PubMedGoogle Scholar
  24. 24.
    Seyer JM, Hutcheson ET, Kang AHC: Collagen polymorphism in normal and cirrhotic human liver. J Clin Invest 59:241–248, 1977PubMedGoogle Scholar
  25. 25.
    Bayerdorffer E, Lamerz R, Fleige R, Kopcke W, Mannes GA: Predictive value of serum procollagen-III-peptide for the survival of patients with cirrhosis. J Hepatol 13:298–304, 1991PubMedGoogle Scholar
  26. 26.
    Hayasaka A, Schuppan D, Ohnishi K, Hahn EG: Serum concentration of the carboxy terminal cross-linking domain of procollagen type IV (NCI) and the aminoterminal propeptide of procollagen type III (PIIIP) in chronic liver diseases. J Hepatol 10:17–22, 1990PubMedGoogle Scholar
  27. 27.
    Preedy VR, Moniz C, Hammond B, Baldwin D, Petero TJ: Changes in bone collagen content after chronic ethanol feeding. Bone 11:222, 1990. (abstract)Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • D. Y. Lin
    • 1
  • C. M. CHU
    • 1
  • I. S. Sheen
    • 1
  • Y. F. Liaw
    • 1
  1. 1.From the Liver UnitChang Gung Memorial Hospital and Chang Gung Medical College TaipeiTaiwan

Personalised recommendations