Comparative evaluation of four different99mTc-sulfur colloid kits used for liver scanning
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The distribution of four different commercially available A, B, C, D kits (99mTc-sulfur colloid) for hepatoimaging was compared in mice by organ radioassay and in rabbits for blood clearance. The distribution of kits A and C (single step kits) was assessed in the human by blood clearance, external liver, spleen measurement, and scintillation camera imaging. Kit A reaches a high concentration in liver within 15–20 minutes with relatively high surrounding tissue background, and superior spleen scintiphotos. However, when kit C was used, a high activity concentration in the liver was reached within 10–15 minutes with low tissue background and faint visualization of the radiotracer in the spleen. Blood clearance of the four99mTc-sulfur colloids was determined in rabbits. The data obtained indicated that the four hepatoagents exhibit rapid blood clearance but the initial decrease of blood activity curve of kit D was relatively faster than the other three hepatic agents. The biodistribution is similar for the four99mTc-S-colloids but the blood retained higher activity residue using kit A compared with others. The formation of99mTc-sulfur colloid using kits B, D (multistep kits) involves many steps after the addition of99mTcO 4 − to the reagent. These procedures are time consuming, required facilities at the medical institutions and give rise to the radiation exposure. While single step kits A and C have the same diagnostic value, the use of kit C allows a reduction of absorbed radiation, which may be useful in the liver exploration in children.
KeywordsActivity Concentration Activity Curve Camera Imaging Initial Decrease Blood Clearance
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