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Statistical analysis of the results of99mTc-MDP quality control

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Abstract

The methods used for control of radiochemical purity of99mTc-MDP are presented. TLC method on silica gel, developed with methanol and acetone (1∶1 v/v), was convenient for determination of99mTcO −4 with the content of 2.6±1.2%. The reliable results on detection of99mTc hydrolyzate (2.2±1.3%) and for another99mTc-MDP complex (13.2±2.8%) were obtained by application of ITLC (SA), developed with Sn-MDP. By Sephadex G-25 column chromatography (1.5 cm×5 cm) the separation of99mTcO −4 was not achieved. The range of normal99mTc-MDP biodistribution values in the organs of experimental animals have been determined. The mean value of bone distribution was 8.4±1.13%/g, in muscles 0.071±0.033%/g, while uptake in liver and kidneys was below 5%. Chi-square test and P show that the results on biodistribution of99mTc-MDP in liver, bones and muscles are arranged around their mean values, which is statistically allowed.

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Authors and Affiliations

  1. The Boris Kidrič Institute of Nuclear Sciences, Vinča, Yugoslavia

    V. Jovanović, R. Vukanović, T. Maksin & M. S. Jovanović

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  1. V. Jovanović
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  2. R. Vukanović
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  3. T. Maksin
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  4. M. S. Jovanović
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Jovanović, V., Vukanović, R., Maksin, T. et al. Statistical analysis of the results of99mTc-MDP quality control. Journal of Radioanalytical and Nuclear Chemistry, Articles 111, 129–135 (1987). https://doi.org/10.1007/BF02060529

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  • DOI: https://doi.org/10.1007/BF02060529

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