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An improved model system for the study of bone repair

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Abstract

A model system for the study of bone repair has been developed which allows the recovery of repairing osseous tissue for qualitative and quantitative evaluation. Nylon tubes were implanted in the alveoli of extracted incisors in guinea pigs. A histological study of longitudinal sections showed that the nylon implants did not delay the reparative processes of the bony defect, could be dissected out and contained sufficient tissue to be used in biochemical studies.

Résumé

Um modèle expérimental, destiné à l'étude de la cicatrisation osseuse, est mis au point. Il permet d'obtenir du tissu osseux pour des études qualitatives et quantitatives. Des tubes de nylon sont implantés dans l'alvéole d'incisives extraites de cobayes. Une étude histologique de coupes longitudinales montrent que les implants de nylon ne retardent pas la cicatrisation des lésions osseuses et contiennent suffisamment de tissus pour des études biochimiques.

Zusammenfassung

Es wurde ein Modellsystem zum Studium der Knochenwiederherstellung entwickelt, mit Hilfe dessen man von dem sich wiederbildenden Knochengewebe Proben für die qualitative und quantitative Bestimmung entnehmen kann. Dazu wurden in die Alveolen extrahierter Schneidezähne von Meerschweinchen Nylonschläuchlein eingelegt. Die histologische Untersuchung von Längsschnitten zeigte, daß die Nylonimplantate den Wiederherstellungsprozeß des Knochendefektes nicht verzögerten, daß sie herauspräpariert werden konnten und genügend Gewebe enthielten, um für biochemische Untersuchungen verwendet zu werden.

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Klouda, G.L., Navia, J.M. An improved model system for the study of bone repair. Calc. Tis Res. 14, 245–249 (1974). https://doi.org/10.1007/BF02060298

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  • DOI: https://doi.org/10.1007/BF02060298

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