Heart and Vessels

, Volume 2, Issue 2, pp 87–90 | Cite as

Changes in coronary flow following repeated brief coronary occlusion in the conscious dog

  • Masatoshi Fujita
  • Daniel P. McKown
  • Michael D. McKown
  • Dean Franklin
Originals

Summary

Studies were conducted in 12 conscious, unsedated dogs instrumented for measurements of subendocardial segment length in the area perfused by the left circumflex coronary artery, blood flow velocity of this artery, and left ventricular pressure. An externally inflatable pneumatic occluder was placed to occlude the circumflex coronary artery for selected durations at selected intervals. Resting coronary blood flow velocity was measured before and after collateral development induced by repeated brief coronary occlusion. Under conditions of comparable myocardial oxygen consumption, shown by the similar pressure-rate product, preocclusion resting coronary blood flow velocity of the repeatedly occluded artery decreased by 21.3% (P<0.001) in association with collateral growth. These findings strongly suggest that the perfusion territory of the collateralized artery decreases considerably secondary to the periodic ischemic stimulus.

Key words

Collateral development Coronary occlusions Coronary perfusion territory Doppler flowmeter Myocardial regional function 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Litvak J, Siderides LE, Vineberg AM (1957) The experimental production of coronary artery insufficiency and occlusion. Am Heart J 53: 505–518PubMedGoogle Scholar
  2. 2.
    Khouri EM, Gregg DE, Lowensohn HS (1968) Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ Res 23: 99–109PubMedGoogle Scholar
  3. 3.
    Franklin D, McKown D, McKown M, Hartley J, Caldwell M (1981) Development and regression of coronary collaterals induced by repeated, reversible ischemia in dogs (abstract). Fed Proc 40: 339Google Scholar
  4. 4.
    Schaper W (1967) Tangential wall stress as a molding force in the development of collateral vessels in the canine heart. Experientia 23: 595–596PubMedGoogle Scholar
  5. 5.
    Elliot, EC, Jones EL, Bloor CM, Leon AS, Gregg DE (1968) Day-to-day changes in coronary hemodynamics secondary to constriction of circumflex branch of left coronary artery in conscious dogs. Circ Res 22: 237–250PubMedGoogle Scholar
  6. 6.
    Schaper W, De Brabander M, Lewi P (1971) DNA synthesis and mitoses in coronary collateral vessels of the dog. Circ Res 28: 671–679PubMedGoogle Scholar
  7. 7.
    Bloor CM, White FC (1972) Functional development of the coronary collateral circulation during coronary artery occlusion in the conscious dog. Am J Pathol 67: 483–500PubMedGoogle Scholar
  8. 8.
    Tomoike H, Franklin D, Kemper WS, McKown D, Ross J Jr (1981) Functional evaluation of coronary collateral development in conscious dogs. Am J Physiol 241: H519–524PubMedGoogle Scholar
  9. 9.
    Hill RC, Kleinman LH, Tiller WH Jr, Chitwood WR Jr, Rembert JC, Greenfield JC Jr (1983) Myocardial blood flow and function during gradual coronary occlusion in awake dogs. Am J Physiol 244: H60-H67PubMedGoogle Scholar
  10. 10.
    Theroux P, Franklin D, Ross J Jr, Kemper WS (1974) Regional myocardial function during acute coronary artery occlusion and its modification by pharmacologic agents in the dog. Circ Res 35: 896–908PubMedGoogle Scholar
  11. 11.
    Vatner SF, Franklin D, VanCitters RL (1970) Simultaneous comparison and calibration of the Doppler and electromagnetic flowmeter. J Appl Physiol 29: 907–910PubMedGoogle Scholar
  12. 12.
    Olsson RA, Gregg DE (1965) Myocardial reactive hyperemia in the unanesthetized dog. Am J Physiol 208: 224–230PubMedGoogle Scholar
  13. 13.
    Gould KL, Lipscomb K, Hamilton GW (1974) Physiologic basis for assessing critical coronary stenosis: Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol 33: 87–94PubMedGoogle Scholar
  14. 14.
    Takahashi M, McKown D, McKown M, Franklin D (1982) Regional myocardial function and reactive hyperemia in conscious dogs during coronary collateral regression (abstract). Circulation 66 [Suppl II–1]Google Scholar
  15. 15.
    Rubio R, Berne RM (1975) Regulation of coronary blood flow. Prog Cardiovasc Dis 18: 105–122PubMedGoogle Scholar
  16. 16.
    Mohrman DE, Feigl EO (1978) Competition between sympathetic vasoconstriction and metabolic vasodilatation in the canine coronary circulation. Circ Res 42: 79–86PubMedGoogle Scholar
  17. 17.
    Scheel KW, Galindez TA, Cook B, Rodriquez RJ, Ingram LA (1976) Changes in coronary and collateral flows and adequacy of perfusion in the dog following one and three months of circumflex occlusion. Circ Res 39: 654–658PubMedGoogle Scholar
  18. 18.
    Hirzel HO, Sonnenblick EH, Kirk ES (1977) Absence of a lateral border zone of intermediate creatine phosphokinase depletion surrounding a central infarct 24 hours after acute coronary occlusion in the dog. Circ Res 41: 673–683PubMedGoogle Scholar
  19. 19.
    Factor SM, Okun EM, Kirk ES (1981) The histological lateral border of acute canine myocardial infarction: a function of microcirculation. Circ Res 48: 640–649PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Masatoshi Fujita
    • 1
  • Daniel P. McKown
    • 1
  • Michael D. McKown
    • 1
  • Dean Franklin
    • 1
  1. 1.Dalton Research CenterUniversity of Missouri-ColumbiaColumbiaU.S.A.

Personalised recommendations