Heart and Vessels

, Volume 4, Issue 2, pp 79–87 | Cite as

Paired pulse pacing increases cardiac O2 consumption for activation without changing efficiency of contractile machinery in canine left ventricle

  • Hiroyuki Suga
  • Shiho Futaki
  • Nobuaki Tanaka
  • Yoshio Yasumura
  • Takashi Nozawa
  • Dequan Wu
  • Yuichi Ohgoshi
  • Hitoshi Yaku
Originals

Summary

The relation between cardiac O2 consumption (Vo2) and the total mechanical energy (TME) generated by contraction was studied under paired-pulse (PP) pacing and compared with that under single-pulse pacing at the same basic rate as PP pacing and at the double-pacing rate in ten excised cross-circulated canine left ventricles (LV). TME was assessed by the systolic pressure-volume (P–V) area (PVA) defined as the area bounded by the end-systolic and end-diastolic P–V curves and the systolic P–V trajectory. The Vo2-PVA relation was linear under PP pacing as well as at control and double heart rates. PP pacing increased LV contractility index Emax from 6.3±3.3 (SD) to 18.0±8.6 mmHg/(ml/100 g) and elevated markedly the Vo2-PVA relation by increasing the Vo2-axis intercept (or PVA-independent Vo2) from 0.62±0.11 to 1.13±0.35 J · beat−1 · 100 g−1. However, PP pacing did not change the slope of the Vo2-PVA relation at 2.24±0.53 (dimensionless). The efficiency from PVA-dependent Vo2 (total Vo2-PVA-independent Vo2) to PVA (= TME), calculated as the reciprocal of the slope of the Vo2-PVA relation, was also constant at 47±11% regardless of PP pacing. These results are similar to previous results obtained by positive inotropic interventions with catecholamines and Ca2+. We conclude that PP pacing augments the PVA-independent Vo2 for activation without affecting the efficiency of the contractile machinery to generate TME from the PVA-dependent Vo2.

Key words

Heart Cardiac energetics Pressure-volume area Excitation-contraction coupling Efficiency 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Hiroyuki Suga
    • 1
  • Shiho Futaki
    • 1
  • Nobuaki Tanaka
    • 1
  • Yoshio Yasumura
    • 1
  • Takashi Nozawa
    • 1
  • Dequan Wu
    • 2
  • Yuichi Ohgoshi
    • 1
  • Hitoshi Yaku
    • 1
  1. 1.Department of Cardiovascular DynamicsNational Cardiovascular Center (NCVC) Research InstituteSuitaJapan
  2. 2.Guizhou Provincial Institute of Cardiovascular DiseasesPeople's Republic of China, invited to NCVC by the Takeda Science Foundation of JapanJapan

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