Hemostatic studies in patients with infective endocarditis: a report on nine consecutive cases with evidence of coagulopathy
- 20 Downloads
Local and generalized changes in coagulation may be important in the genesis of vegetations and embolism in infective endocarditis. To characterize such alterations, serial hematological investigations were performed on nine consecutive patients who satisfied the inclusion criteria. Platelet survival was measured by Indium111 labeling. Acute and convalescent samples were analyzed for fibrinogen, factor VIIIc, antithrombin III (AT III), fibrin/fibrinogen degradation products (FDPs), and platelet aggregation. The results suggest that in the active stage of the disease: (1) hypercoagulability may be caused by a rise in acute phase reactants, (2) an acceleration of coagulation and fibrinolysis may supervene, and (3) in some cases there is a reduction in platelet aggregation, possibly as a result of continued circulation of previously activated “exhausted” platelets.
Key wordsEndocarditis Coagulation Clotting factors AT III Platelets
Unable to display preview. Download preview PDF.
- 3.Taha TH, Durrant S, Crick JCP, Oakley CM (1988) Hypercoagulability, consumptive coagulopathy and paradoxical reduction of platelet aggregation in infective endocarditis (abstract). Br Heart J 59: 129Google Scholar
- 5.Dacie JV, Lewis SM (1984) Practical haematology. Churchill Livingstone, Edinburgh, pp 232–233Google Scholar
- 6.Meade T, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imeson JD, Thompson SG (1986) Haemostatic function and ischaemic heart disease: Principal results of Northwick Park Heart Study. Lancet II: 533–537Google Scholar
- 8.Stuart JJ, Breyer R (1984) Subacute bacterial endocarditis causing disseminated intravascular coagulation: Resolution after valve replacement. J Thorac Cardiovasc Surg 88: 454–456Google Scholar
- 10.Delcampo C (1985). Resolution of disseminated intravascular coagulation after valve replacement (letter). J Thorac Cardiovas Surg 89: 470–471Google Scholar
- 15.Salzman EW (1963) Blood platelets and extra corporeal circulation transfusion. Transfusion 3: 274–277Google Scholar
- 19.Taha TH, Durrant SS, Mazeika PK, Nihoyannopoulos P, Oakley CM (1990) Aspirin to prevent growth of vegetations and cerebral emboli in infective endocarditis. Circulation (Suppl III) 82: III-420Google Scholar