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Heart and Vessels

, Volume 6, Issue 2, pp 71–83 | Cite as

Hyperthyroid dog left ventricle has the same oxygen consumption versus pressure-volume area (PVA) relation as euthyroid dog

  • Hiroyuki Suga
  • Nobuaki Tanaka
  • Yuichi Ohgoshi
  • Yasutake Saeki
  • Toshio Nakanishi
  • Shiho Futaki
  • Hitoshi Yaku
  • Yoichi Goto
Originals

Summary

We studied the effects of hyperthyroidism on the relation between O2 consumption (Vo2) and the pressure-volume area (PVA) of the left ventricle (LV) in dogs. PVA is a measure of the total mechanical energy generated per beat of LV. Dogs were treated by daily intramuscular injection of 0.3 or 1.0 mg/kgl-thyroxine over 2–5 weeks. Hyperthyroid dogs had a 40 times higher serum T4, a 40% higher sinus heart rate, and a 35% higher LV Emax (an index of ventricular contractility) than euthyroid dogs. Hyperthyroid dog hearts had linearVo2-PVA relations like euthyroid dog hearts. The regression line wasVo2=A×PVA+B, where A was 2.30 (dimensionless) and B was 0.53 J/beat per 100 g LV. B was significantly increased with dobutamine and decreased with propranolol, whereas A was not significantly changed by them. These A and B values were comparable to euthyroid data. Hyperthyroidism did not significantly affect myosin Ca-ATPase activity and V3-type myosin predominance, but increased the speed of the force transient response to length perturbation by 20%–70%, suggesting similar increases in crossbridge cycling rate. We conclude that in spite of accelerated crossbridge cycling rate theVo2-PVA relation was not altered by hyperthyroidism in dogs.

Key Words

Thyroid hormone Heat economy Contractile efficiency Total mechanical energy 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Hiroyuki Suga
    • 1
  • Nobuaki Tanaka
    • 1
  • Yuichi Ohgoshi
    • 1
  • Yasutake Saeki
    • 1
    • 2
  • Toshio Nakanishi
    • 1
    • 3
  • Shiho Futaki
    • 1
  • Hitoshi Yaku
    • 1
  • Yoichi Goto
    • 1
  1. 1.Department of Cardiovascular DynamicsNational Cardiovascular Center Research InstituteSuita, OsakaJapan
  2. 2.Department of PhysiologyTsurumi University School of Dental MedicineYokohamaJapan
  3. 3.Department of Pediatric Cardiology, Heart Institute of JapanTokyo Women's Medical CollegeTokyoJapan

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