Diseases of the Colon & Rectum

, Volume 39, Issue 5, pp 536–540 | Cite as

A twenty-year review of malignant colorectal neoplasms at University College Hospital, Ibadan, Nigeria

  • Y. Iliyasu
  • J. K. Ladipo
  • E. E. U. Akang
  • C. A. Adebamowo
  • O. G. Ajao
  • P. U. Aghadiuno
Original Contributions
  • 24 Downloads

Abstract

PURPOSE: Colorectal malignancies are less common in developing than developed nations because of lowerper capitaincome and higher dietary fiber consumption. This clinicopathologic study attempts to determine changes in the pattern of these neoplasms in Ibadan, Nigeria, during the last two decades. METHODS: The present study is based on the clinical Cancer Registry records and gross and morphologic surgical pathology findings of 526 patients with histologically verified malignant colorectal neoplasms received in the Department of Pathology, University College Hospital, Ibadan, between 1971 and 1990. RESULTS: Colonic malignancies increased by 81 percent, whereas rectal malignancies decreased 16.1 percent in frequency (P<0.05). The modal ages were 55 to 60 years and 45 to 50 years for colonic and rectal neoplasms, respectively, in contrast to reported peak occurrence in the seventh decade among Caucasians. Colonic neoplasms were predominantly right-sided (34.3 percent cecal), abdominal mass and pain being major clinical manifestations. This differs from the pattern in American Negroes, among whom colonic carcinomas are predominantly left-sided, dyschezia being an important presentation. As in most other studies, adenocarcinomas were the predominant neoplasms. CONCLUSIONS: Further work is required to determine prognostically significant features of colorectal cancer in our environment.

Key words

Colorectal neoplasms Colonic Rectal Pathology Nigeria Polyps Polyposis coli Familial 

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References

  1. 1.
    Vogel VG, McPherson RS. Dietary epidemiology of colon cancer. Hematol Oncol Clin North Am 1989;3:35–63.PubMedGoogle Scholar
  2. 2.
    Burkitt DP. Related disease—related cause? Lancet 1969;2:1229–30.PubMedGoogle Scholar
  3. 3.
    Edington GM, Maclean CM. A cancer rate survey in Ibadan, Western Nigeria, 1960–1963. Br J Cancer 1965;19:471–81.Google Scholar
  4. 4.
    Ajao OG. Colon and anorectal neoplasms in a tropical African population. Int Surg 1979;64:47–52.Google Scholar
  5. 5.
    Williams AO, Edington GM. Malignant disease of the colon, rectum and anal canal in Ibadan, Western Nigeria. Dis Colon Rectum 1967;10:301–8.PubMedGoogle Scholar
  6. 6.
    Bremner CG, Ackerman LV. Polyps and carcinoma of the large bowel in the South African Bantu. Cancer 1970;26:991–9.PubMedGoogle Scholar
  7. 7.
    Grillo IA, Bond LF, Ebong WW. Cancer of the colon in Nigerians and American Negroes. J Natl Med Assoc 1971;63:357–61.PubMedGoogle Scholar
  8. 8.
    El-Masri SH, Boulos PB. Carcinoma of the large bowel in the Sudan. Br J Surg 1975;62:284–6.PubMedGoogle Scholar
  9. 9.
    Ngala-Kenda JF. Cancer of the large bowel in African: a 15 year survey at Kinshasa University Hospital, Zaire. Br J Surg 1976;63:966–8.PubMedGoogle Scholar
  10. 10.
    Adekunle OO, Abioye AA. Adenocarcinoma of the large bowel in Nigerians: a clinicopathologic study. Dis Colon Rectum 1980;23:559–63.PubMedGoogle Scholar
  11. 11.
    Ajao OG, Adenuga MO, Ladipo J. Colorectal carcinoma in patients under the age of 30 years: a review of 11 cases. J R Coll Surg Edinb 1988;33:277–9.PubMedGoogle Scholar
  12. 12.
    Mabogunje AL, McCaskie TC, Smith P. Nigeria. Africa South of the Sahara 1993. 2nd ed. London: Europa Publications, 1992:662–9.Google Scholar
  13. 13.
    Mabogunje AL, Harrison Church RJ, McCaskie TC, Hackett P. Nigeria. Africa South of the Sahara. 15th ed. London: Europa Publications, 1985:723–64.Google Scholar
  14. 14.
    Belo-Osagie K, Graf WD, Synge R, Williams G, Rake A. In: Rake A, ed. NewAfrican Yearbook—East, South Africa and Nigeria—1984–85. New York: IC Magazines, 1984:187–216.Google Scholar
  15. 15.
    Federal Office of Statistics: Economic and statistical review 1980–1990. Lagos, Nigeria, pp 110.Google Scholar
  16. 16.
    Morson BC, Sobin LH. Histological typing of intestinal tumours. In: Morson BC, Sobin LH, eds. International histological classification of tumors, no. 15. Geneva: World Health Organization, 1976.Google Scholar
  17. 17.
    Dukes CE. Histologic grading of rectal carcinoma. J R Soc Med 1937;30:371.Google Scholar
  18. 18.
    Elmes BG, Baldwin RB. Malignant disease in Nigeria: an analysis of 1000 tumors. Ann Trop Med Parasitol 1947;41:321–8.Google Scholar
  19. 19.
    Golden T, Stout AP. Smooth muscle tumors of gastrointestinal tract and retroperitoneal tissues. Surg Gynecol Obstet 1941;73:784–810.Google Scholar
  20. 20.
    Zakariai YM, Quan SH, Hajdu SI. Carcinoid tumors of the gastrointestinal tract. Cancer 1975;35:588–91.PubMedGoogle Scholar
  21. 21.
    Oettle AG. Cancer in Africa especially in regions South of the Sahara. J Natl Cancer Inst 1964;33:383–439.PubMedGoogle Scholar
  22. 22.
    Williams AO, Prince DL. Intestinal polyps in the Nigerian African. J Clin Pathol 1975;28:367–71.PubMedGoogle Scholar
  23. 23.
    Williams AO, Chung EB, Agbata A, Jackson MA. Polyps in American Negroes and Nigerian Africans. Br J Cancer 1975;31:485–91.PubMedGoogle Scholar
  24. 24.
    Harris HF. Amebic dysentery. Am J Med Sci 1898;115:384.Google Scholar

Copyright information

© American Society of Colon and Rectal Surgeons 1996

Authors and Affiliations

  • Y. Iliyasu
    • 1
  • J. K. Ladipo
    • 2
  • E. E. U. Akang
    • 1
  • C. A. Adebamowo
    • 2
  • O. G. Ajao
    • 2
  • P. U. Aghadiuno
    • 1
  1. 1.Department of PathologyUniversity College HospitalIbadanNigeria
  2. 2.Department of SurgeryUniversity College HospitalIbadanNigeria

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