Mycopathologia et mycologia applicata

, Volume 6, Issue 4, pp 290–297 | Cite as

Candida albicans infections in actively and passively immunized animals

  • R. C. Hurd
  • C. H. Drake

Summary and Conclusions

1. The literature on the pathology and immunology ofCandida albicans is briefly reviewed.

2. Experimental methods and techniques used in this study are presented.

3. Experimental observations described here show that:

  1. a

    Many of the lesions found differed from those described byCecil andJacobson.

  2. b

    The immunization did not seem to preserve the life of the animal nor did it extend the survival time over that of the controles, the general impression being that it was not only ineffective but possibly deleterious.

  3. c

    The antiserum seemed to have some effect on the morphology of the organisms shown by the multibranched mycelium, the thick-walled, distorted blastospores, the heavy packing of the organisms in some cases and the presence of typical “sulfur granules”, the actinomycetoid form of the organisms, in a number of animals.

  4. d

    The antiserum seemed to have little or not effect on the tissue reactions.



Sulfur Survival Time Experimental Method Candida Experimental Observation 

Sommaire et Conclusions

1. La littérature concernant la pathologie et l'immunologie deCandida albicans est brièvement passée en revue.

2. Les méthodes d'experimentation et les techniques employées dans cette étude sont presentées.

3. Les observations faites pendant les experiences montrent que:

  1. a

    Beaucoup des lésions trouvées differaient de celles décrites parCecil etJacobson.

  2. b

    L'immunisation n'a pas semblé préserver la vie de l'animal ni prolonger la période de survie au dela de celle des animaux de contrôle. L'impression générale est que l'immunisation fut, non seulement inefficace, mais peut-être nuisible.

  3. c

    L'antisérum semble avoir eu, sur la morphologie des organismes, quelque effet démontré par le mycélium multibranche, les blastospores tordus aux parois épaisses, dans certains cas un conglomérat très dense des organismes et la présence de typiques “sulfur granules”, la forme actoinomycetoide des organismes chez un certain nombre d'animaux.

  4. d

    L'antisérum semble avoir eu peu ou pas d'effet sur la réaction tissulaire.



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Copyright information

© Uitgeverij Dr. W. Junk 1953

Authors and Affiliations

  • R. C. Hurd
    • 1
  • C. H. Drake
    • 1
  1. 1.Department of Bacteriology and Public HealthState College of Washington PullmanUSA

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