Abstract
A case of locally extensive perianal Paget's disease is presented. Initial wide local excision, guided by frozen sections, was inadequate. Multiple punch biopsies subsequently revealed extensive circumferential involvement of the anoderm by Paget's disease, making wide local excision difficult. Therefore, the patient was treated with combined chemoradiotherapy (5000 cGy, 5-fluorouracil, and mitomycin C). Fourteen months after treatment, the patient had a complete response.
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References
Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St Bartholomew Hosp Res London 1874;10:87–9.
Beck DE, Fazio VW. Perianal Paget's disease. Dis Colon Rectum 1987;30:263–6.
Flam MS, John MJ, Mowry PA, Lovalvo LJ, Ramalho LD, Wade J. Definitive combined modality therapy of carcinoma of the anus: a report of 30 cases including results of salvage therapy in patients with residual disease. Dis Colon Rectum 1987;30:495–502.
Enker WE, Heilwell M, Janov AJ, et al. Improved survival in epidermoid carcinoma of the anus in association with preoperative multidisciplinary therapy. Arch Surg 1986;121:1386–90.
Fligiel Z, Kaneko M. Extramammary Paget's disease of the external ear canal in association with ceruminous gland carcinoma: a case report. Cancer 1975;36:1072–6.
Worthon CM, Patterson JB. Carcinoma of Moll's glands with extramammary Paget's disease of the eyelid. Cancer 1955;8:1009–15.
Pitman GH, McCarthy JG, Perzin KH, Herter FP. Extramammary Paget's disease. Plast Reconstr Surg 1982;69:238–44.
Tjandra J. Perianal Paget's disease: report of three cases. Dis Colon Rectum 1988;31:462–66.
Armitage NC, Jass JR, Richman PI, Thompson JPS, Phillips RK. Paget's disease of the anus: a clinicopathological study. Br J Surg 1989;76:60–3.
Berardi RS, Lee S, Chen HP. Perianal extramammary Paget's disease. Surg Gynecol Obstet 1988;167:359–66.
Jensen SL, Sjolin KE, Shokouh-Amiri MH, Hagen K, Harling H. Paget's disease of the anal margin. Br J Surg 1988;75:1089–92.
Giltman LI, Osborne PT, Coleman SA, Uthman EO. Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features. J Surg Oncol 1985;28:277–80.
Subbuswamy SG, Ribeiro BF. Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. Dis Colon Rectum 1981;24:535–8.
Ordonez NG, Awalt H, Mackay B. Mammary and extramammary Paget's disease: an immunocytochemical and ultrastructural study. Cancer 1987;59:1173–83.
Wood WS, Culling CF. Perianal Paget's disease: histochemical differentiation utilizing the borohydride-KOH-PAS reaction. Arch Pathol 1975;99:442–5.
Jones RE, Austin C, Ackerman AB. Extramammary Paget's disease: a critical reexamination. Am J Dermatopathol 1979;1:101–32.
Grow JR, Kshirsagar V, Tolentino M, Gramling J, Schutte AG. Extramammary perianal Paget's disease: report of a case. Dis Colon Rectum 1977;20:436–42.
Leichman L, Nigro N, Vaitkevicius VK, et al. Cancer of the anal canal: model for preoperative adjuvant combined modality therapy. Am J Med 1975;78:211–12.
Sischy B, Graney MJ, Hinson EJ, Qazi R. Preoperative radiation therapy with sensitizers in the management of carcinoma of the rectum. Dis Colon Rectum 1985;28:56–7.
Buroker T, Nigro N, Correa J, Vaitkevicius VK, Samson M, Considine B. Combination preoperative radiation and chemotherapy in adenocarcinoma of the rectum: preliminary report. Dis Colon Rectum 1976;19:660–3.
Secco GB, Lapertosa G, Sertoli MR, Scarpati D, Riboli EB. Perianal Paget's disease: case report of an elderly patient treated with polychemotherapy and radiotherapy. Tumori 1984;70:381–3.
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Thirlby, R.C., Hammer, C.J., Galagan, K.A. et al. Perianal Paget's disease: Successful treatment with combined chemoradiotherapy. Dis Colon Rectum 33, 150–152 (1990). https://doi.org/10.1007/BF02055547
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DOI: https://doi.org/10.1007/BF02055547