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Cytology of four yeastlike organisms in tissue explants

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Mycopathologia et mycologia applicata Aims and scope Submit manuscript

Summary

Tissue ‘explants’ from mice infected with ‘deep fungi’ revealed that:

  1. 1.

    B. dermatitidis andS. schenckii produce giant and bizarre yeast cells several times the diameter ordinarily seen in tissues.

  2. 2.

    Cytologic variations inC. neoformans andC. albicans are much less pronounced.

It appears that the accumulation of excessive cytoplasm and the giant size of the cells is related to lack of division of the organisms in the autolyzing tissue.

Similar bizarre forms ofB. dermatitidis, S. schenckii, andH. capsulatum in necrotic foci of spontaneous or experimental disease in animals originate, in all probability, by the same mechanism.

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Literature

  • Schwarz, J. 1953. Giant forms ofHistoplasma capsulatum in tissue explants. Amer. J. Clin. Path.23: 898–903.

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  • Pine, L., Drouhet, E. &Reynolds, G. 1964. A comparative study of the yeast phases ofHistoplasma capsulatum andHistoplasma duboisii. Sabouraudia3: 211–223.

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  • Okudaira, M., Tsubura, E. &Schwarz, J. 1961. A histopathological study of experimental murine sporotrichosis. Mycopath. et Mycol. appl.14: 284–296.

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  • Lurie, H. E. 1963. Histopathology of sporotrichosis. Arch. Path.75: 421–437.

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Authors and Affiliations

  1. From the Clinical Laboratories of Jewish Hospital, Cincinnati, Ohio

    Jan Schwarz

Authors
  1. John N. Goldman
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  2. Jan Schwarz
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Additional information

This research was supported in part by Grant E-576 from the National Institute of Health.

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Goldman, J.N., Schwarz, J. Cytology of four yeastlike organisms in tissue explants. Mycopathologia et Mycologia Applicata 29, 161–167 (1966). https://doi.org/10.1007/BF02055074

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  • DOI: https://doi.org/10.1007/BF02055074

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