Zeitschrift für die gesamte experimentelle Medizin

, Volume 128, Issue 2, pp 140–147 | Cite as

Beobachtungen über den zeitlichen Ablauf der Leberschädigung durch Tetrachlorkohlenstoff bei der Ratte

  • Nepomuk Zöllner
  • Edith Raisich
Article

Summary

  1. 1.

    Succinoxidase and succinic dehydrogenase of rat liver homogenates were studied at various intervals after a single intraperitoneal injection of carbon tetrachloride (0,07–0,4 g/100 g animal).

     
  2. 2.

    The activities of both enzymes show a significant decrease as early as two hours after carbon tetrachloride application, the lowest value being reached after about 10 hours.

     
  3. 3.

    Restitution of enzyme activity is slow, needing 5 to 6 days.

     
  4. 4.

    The amount of carbon tetrachloride administered has only an influence on the degree of the changes but not on their time-course.

     
  5. 5.

    These results are correlated with histologic studies.

     
  6. 6.

    Some implications of the results are discussed. The rapidity of the enzymatic assay, as compared to histological studies, is pointed out.

     

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Copyright information

© Springer-Verlag 1956

Authors and Affiliations

  • Nepomuk Zöllner
    • 1
  • Edith Raisich
    • 1
  1. 1.Medizinischen Poliklinik der Universität MünchenDeutschland

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