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New paradigms of oncogenesis and their implications for surgery in the twenty-first century

  • The Norman Nigro Lectureship
  • Published:
Diseases of the Colon & Rectum

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References

  1. Kuhn TS. The structure of scientific revolutions. 2nd ed. Chicago: The University of Chicago Press, 1970.

    Google Scholar 

  2. Naj AK. Researchers isolate bacteria protein than can store data in 3 dimensions. Wall Street Journal 1991 September 4;B4.

  3. Katon M, Parker PJ. Oncogenes and cell control. Nature 1988;332:203.

    Google Scholar 

  4. Simpson PC. Proto-oncogenes and cardiac hypertrophy. Annu Rev Physiol 1988;51:189–202.

    Google Scholar 

  5. Friend SH, Dryja TP, Weinberg RA. Oncogenes and tumor-suppressing genes. N Engl J Med 1988;318:618–22.

    Article  CAS  PubMed  Google Scholar 

  6. Malkin D, Li FP, Strong LC,et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990;250:1233–8.

    CAS  PubMed  Google Scholar 

  7. Cance WC, Brennan MF, Dudas ME, Huang C-M, Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 1990;323:1457–62.

    Article  CAS  PubMed  Google Scholar 

  8. Laiho M, DeCarpio JA, Ludlow JW, Livingston DM, Massogue J. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 1990;62:175–85.

    CAS  PubMed  Google Scholar 

  9. Sidransky D, Von Eschenbach A, Tsau YC,et al. Identification of p53 gene mutations in bladder cancers and urine samples. Science 1991;252:706–9.

    CAS  PubMed  Google Scholar 

  10. Campbell-Boswell M, Robertson A. Effects of angiotensin II and vasopressin on human smooth muscle cellsin vitro. Exp Mol Pathol 1981;35:265–76.

    CAS  PubMed  Google Scholar 

  11. Powell JS, Clozel J-P, Muller RKM,et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 1989;254:186–8.

    Google Scholar 

  12. Chobanian AV, Houdenschild CC, Nickerson C, Drago R. Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit. Hypertension 1990;15:327–31.

    CAS  PubMed  Google Scholar 

  13. Han JW, McCormick F, Macara IG. Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids. Science 1991;252:576–87.

    CAS  PubMed  Google Scholar 

  14. Warrell RP, Frankel SR, Miller WH,et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 1991;324:1385–93.

    Article  PubMed  Google Scholar 

  15. Zon G. Oligonucleotide analogues as potential chemotherapeutic agents. Pharm Res 1988;5(Suppl 9):539–49.

    CAS  PubMed  Google Scholar 

  16. Rosenberg SA, Lotze MT, Mule JJ. New approaches to the immunotherapy of cancer using interleukin-2. Ann Intern Med 1988;108:853–64.

    CAS  PubMed  Google Scholar 

  17. Bacon K. NIH panel clears first humor tests of gene therapy. Wall Street Journal 1990 August 1;B1.

  18. Nabel EG, Nabel GJ. Gene transfer and cardiovascular disease. Trends Cardiovasc Med 1991;1:12–17.

    CAS  Google Scholar 

  19. Vogelstein B, Fearon ER, Kern SE,et al. Allelotype of colorectal carcinomas. Science 1989;244:207–11.

    CAS  PubMed  Google Scholar 

  20. Kern SE, Fearon ER, Tersmette KW,et al. Clinical and pathological associations with allelic loss in colorectal carcinoma. JAMA 1989;261:3099–103.

    CAS  PubMed  Google Scholar 

  21. Baker SJ, Markowitz S, Fearon ER, Willson JK, Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990;249:912–5.

    CAS  PubMed  Google Scholar 

  22. Baker SJ, Preisinger AC, Jessup JM,et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990;50:7717–22.

    CAS  PubMed  Google Scholar 

  23. Vogelstein B. Cancer. A deadly inheritance. Nature 1990;348:681–2.

    CAS  PubMed  Google Scholar 

  24. Kern SE, Kinzler KW, Baker SJ,et al. Mutant p53 proteins bind DNA abnormallyin vitro. Oncogene 1991;6:131–6.

    CAS  PubMed  Google Scholar 

  25. Kinzler KW, Nilbert MC, Vogelstein B,et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 1991;251:1366–70.

    CAS  PubMed  Google Scholar 

  26. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49–53.

    CAS  PubMed  Google Scholar 

  27. Marx J. Gene identification for inherited cancer susceptibility. Science 1991;253:616.

    CAS  PubMed  Google Scholar 

  28. Re RN. Bioburst: the impact of modern biology on the affairs of man. Baton Rouge: Louisiana State University Press, 1986.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Research, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, 70121, New Orleans, Louisiana

    Richard N. Re M.D. (Vice President and Director)

Authors
  1. Richard N. Re M.D.
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Additional information

Read at the meeting of The American Society of Colon and Rectal Surgeons, Boston, Massachusetts, May 12 to 17, 1991.

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Re, R.N. New paradigms of oncogenesis and their implications for surgery in the twenty-first century. Dis Colon Rectum 35, 627–634 (1992). https://doi.org/10.1007/BF02053751

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  • DOI: https://doi.org/10.1007/BF02053751

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