Abstract
PURPOSE: Because definitive information regarding lymph node status in rectal cancer would be valuable preoperatively, we evaluated the safety, feasibility, and accuracy of performing endoluminal ultrasound-guided biopsies of pararectal lymph nodes in 26 rectal cancer patients. Biopsies were compared with the pararectal tissues removed at surgery. METHODS: Using a longitudinally oriented 7.0-MHz ultrasound probe and an 18-gauge spring-loaded core biopsy needle, patients underwent biopsies of lymph nodes detected ultrasonographically without complications. RESULTS: A biopsy of adenocarcinoma was obtained in 13 patients, lymphoid material in 5 patients, and irrelevant material in 8 patients. Accuracy rate (true positives divided by number of procedures) was 77 percent, with a sensitivity of 71 percent, a specificity of 89 percent, a positive predictive value of 92 percent, and a negative predictive value of 62 percent. When adenocarcinoma or lymphoid material was obtained, there was only one false positive and one false negative. CONCLUSION: Endoluminal ultrasonographyguided lymph node biopsy is simple and safe, and when adenocarcinoma or lymphoid material is obtained on biopsy, clinical decision making can be based on this information.
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References
Krook JE, Moertel CG, Gunderson LL,et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991;324:709–15.
Skibber JM, Rich TA, Schumate CR,et al. Local excision and postoperative radiotherapy for low rectal cancer. Arch Surg (in press).
Minsky BD, Cohen AM, Enker WE, Mies C. Sphincter preservation in rectal cancer by local excision and postoperative radiation therapy. Cancer 1991;76:908–14.
Dukes CE, Bussey HJ. The spread of rectal cancer and its effect on prognosis. Br J Cancer 1958;12:309–20.
Milsom JW, Graffner HO. Intrarectal ultrasonography in rectal cancer staging and in the evaluation of pelvic disease. Ann Surg 1990;212:602–6.
Wilson TM, Guthman DA. Current status of transrectal ultrasonography in the detection of prostate cancer. Oncology 1991;5:73–8.
Milsom JW, Lavery IC, Stolfi VM,et al. The expanding utility of endoluminal ultrasonography in the management of rectal cancer. Surgery 1992;112:832–41.
Glaser F, Schlag P, Herfarth C. Endorectal ultrasonography for the assessment of invasion of rectal tumours and lymph node involvement. Br J Surg 1990;77:883–7.
Beynon J, Mortensen NJ, Foy DM, Channer JL, Rigby H, Virjee J. Preoperative assessment of mesorectal lymph node involvement in rectal cancer. Br J Surg 1989;76:276–9.
Hildebrandt U, Klein T, Feifel G, Schwarz H-P, Koch B, Schmitt RM. Endosonography of pararectal lymph nodes:in vitro andin vivo evaluation. Dis Colon Rectum 1990;33:863–8.
Andersson R, Aus G. Transrectal ultrasound-guided biopsy for verification of lymph-node metastasis in rectal cancer. Acta Chir Scand 1990;156:659–60.
Beynon J, Mortensen NJ, Foy DM, Channer JL, Rigby H, Virjee J. The detection and evaluation of locally recurrent rectal cancer with rectal ultrasonography. Dis Colon Rectum 1989;32:509–17.
Rifkin MD, Alexander AA, Pisarchick J, Matteucci T. Palpable masses in the prostate: accuracy of US-guided biopsy compared with accuracy of digitally guided biopsy. Radiology 1991;179:41–2.
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Winner of the Pennsylvania Society of Colon and Rectal Surgeons Award.
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Milsom, J.W., Czyrko, C., Hull, T.L. et al. Preoperative biopsy of pararectal lymph nodes in rectal cancer using endoluminal ultrasonography. Dis Colon Rectum 37, 364–368 (1994). https://doi.org/10.1007/BF02053598
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DOI: https://doi.org/10.1007/BF02053598