Abstract
To assess the efficacy of sucralfate enemas in distal colonic ulcerative lesions, 22 patients with radiation proctitis (n=8), idiopathic ulcerative proctitis (n=5), and solitary rectal ulcer (n=5) unresponsive to conventional medical therapy, and those with ulcerated and bleeding rectal polyps awaiting polypectomy (n=4) were studied. Enemas of sucralfate suspension (2 gm in 20 ml water) were administered twice daily for a period of three weeks. Clinical and sigmoidoscopic improvements were observed in 19 and 18 of the 22 patients, respectively (86 and 82 percent, respectively). No side effects were seen. The authors conclude that sucralfate enemas are useful in the treatment of ulcerative lesions of the rectosigmoid.
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References
Nagashima R. Development and characteristics of sucralfate. J Clin Gastroenterol 1981;3(suppl 2):103–10.
Shea-Donohue T, Steel L, Montcalm E, Dubois A. Gastric protection by sucralfate: role of mucus and prostaglandins. Gastroenterology 1986;91:660–6.
Hollander D, Taranawski A, Krause WJ, Gergely H. Protective effect of sucralfate against alcohol induced gastric mucosal injury in the rat: macroscopic, histologic, ultrastructural and functional time sequence analysis. Gastroenterology 1985;88:366–74.
Hollander D. Efficacy of sucralfate for duodenal ulcers: a multicenter double blind trial. J Clin Gastroenterol 1981;3(suppl 2):153–7.
Elsborg L. Oesophageal reflux disease: diagnosis, pathophysiology and treatment with special reference to the role of sucralfate. Scand J Gastroenterol 1987;22(suppl 127):101–9.
Tryba M, May B. Acute treatment of severe haemorrhagic gastritis with high dose sucralfate. Lancet 1988;2:1304.
Carling L, Kagevi I, Borvall E. Sucralfate enema (SUC)—effective in IBD? (letter) Endoscopy 1986;18:115.
Batman F. Arslan S, Telatar H. Effect of sucralfate in the treatment of solitary rectal ulcer (letter). Endoscopy 1988;20:128.
Baron JH, Connell AM, Lennard-Jones JE. Variations between observers in describing mucosal appearances in proctocolitis. Br Med J 1964;1:89–92.
Gilinsky NH, Burns DG, Barbezat GO, Levin W, Myers HS, Marks IN. The natural history of radiation induced proctosigmoiditis: an analysis of 88 cases. Quart J Med 1983;205:40–53.
Nagashima R. Mechanisms of action of sucralfate. J Clin Gastroenterol 1981;3(suppl 2):117–27.
Danesh BJ, Duncan A, Russell RI. Is an acid pH medium required for the protective effect of sucralfate against mucosal injury? Am J Med 1987;83(suppl 3B):11–3.
Bronner MH, Yantis PL. Intracolonic sucralfate suspension for postpolypectomy hemorrhage. Gastrointest Endosc 1986;32:362–3.
Dawson DJ, Khan AN, Miller V, Ratcliffe JF, Shreeve DR. Detection of inflammatory bowel disease in adults and children: evaluation of a new isotopic technique. Br Med J 1985:291:1227–30.
Zahavi I, Avidor I, Marcus H, et al. Effect of sucralfate on experimental colitis in the rat (abstract). Gastroenterology 1987;92:1707.
Goldstein F, Khoury J, Thornston JJ. Treatment of chronic radiation enteritis and colitis with salicylazosulphapyridine and systemic corticosteroids. Am J Gastroenterol 1976;65:201–8.
Yeoh EK, Horowitz M. Radiation enteritis. Surg Gynecol Obstet 1987:165:373–9.
Kochhar R, Sharma SC, Gupta BB, Mehta SK. Rectal sucralfate in radiation proctitis (letter). Lancet 1988;2:400.
Kochhar R, Malik AK, Nanda V, Bhasin DK, Singh K, Mehta SK. Clinical spectrum of solitary rectal ulcer. Indian J Gastroenterol 1986;6:31–3.
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Kochhar, R., Mehta, S.K., Aggarwal, R. et al. Sucralfate enema in ulcerative rectosigmoid lesions. Dis Colon Rectum 33, 49–51 (1990). https://doi.org/10.1007/BF02053202
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DOI: https://doi.org/10.1007/BF02053202