Summary
Intravenous injection of mice with a massive dose ofCoccidioides immitis fungal elements caused a moderate inflammatory response after 6 hours. It was composed of small focal collections of lymphocytes and neutrophils surrounding the rounded fungal elements in the mouse lungs. No further change was noted at 24 hours. Spherules with endospores varying in diameter from 15 to 40μ were seen at 48 and 54 hours. Neutrophils persisted throughout this time and increased only minimally; the lymphocytic response was more marked at these later observations.
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In conducting the research reported here, the investigators adhered to “Principles of Laboratory Animal Care” as established by the National Society for Medical Research.
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Sinski, J.T., Soto, P.J. Onset of coccidioidomycosis in mouse lung after intravenous injection. Mycopathologia et Mycologia Applicata 30, 41–46 (1966). https://doi.org/10.1007/BF02051707
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DOI: https://doi.org/10.1007/BF02051707