Mycopathologia et mycologia applicata

, Volume 43, Issue 1, pp 65–87 | Cite as

Epidemiological investigations of oral Candida Albicans

  • J. A. Schmitt
Article

Abstract

Using a gargle-rinse technique, the oral cavities of 103 volunteers were sampled and cultured for the presence ofCandida albicans. Thirty-six (33.95 %) were positive forC. albicans, including 14 females and 22 males. Sixty-four subjects, including negative controls, were placed on treatment regimes of a pre-sleep gargle-rinse with either sterile distilled water (W) or Cepacol® Mouthwash/Gargle (C). The possible effects of ambient temperature, diet, age, sex, and mouthwash use on oralC. albicans levels are illustrated and discussed, including some evidence for familial endemicity. On simulated sporadic or continuous mouthwash use, some individuals showed statistically significant reductions in oralC. albicans flora, whereas others had biologically significant reductions that were not confirmed statistically. A few originally negative individuals developed non-persistent lowC. albicans counts on one or two days. Total bacterial counts were made for 32 subjects, for most of whom biologically significant reductions were obtained, although the counts were highly variable and erratic. The data support the concept that a reduction in oralC. albicans does not lead to an increase in total bacterial flora, and vice versa.

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References

  1. 1.
    Barlow, A. J. E., &Chattaway, F. W. (1969) Observations on the carriage ofCandida albicans in man.Brit. J. Derm. 81:103–106.Google Scholar
  2. 2.
    Bartels, H. A., &Buchbinder, M. (1954) Yeastlike microorganisms isolated from root canals.Oral Surg. 7:98.Google Scholar
  3. 3.
    Benham, Rhoda W., &Hopkins, A. M. (1933) Yeast-like fungi found on the skin and in the intestines of normal subjects.Arch. Dermat. Syph. (Chicago) 28:532.Google Scholar
  4. 4.
    Berge, T., &Kaplan, W. (1967) Systemic candidiasis with asteroid-body formation.Sabouraudia 5:310.Google Scholar
  5. 5.
    Blaschke-Hellmessen, R. (1966) The human yeast flora. An evaluation of routine mycological examinations from 1959 to 1964.Z. Hyg. Grenzgebiete 12:708.Google Scholar
  6. 6.
    Borowski, J., Kaminska, Maria &Michalska, Ewa (1963) Monilia infections in hospitalized children.Ann. Paediat. (Basel) 300:394.Google Scholar
  7. 7.
    Brygoo, E. R. (1952) Etude de 66 souches deCandida isolées a Saigon de prelevanents pharyngiens.Ann. Inst. Pasteur (Paris) 83:818.Google Scholar
  8. 8.
    Cawson, R. A. (1966) Chronic oral candidosis; denture stomatitis, and chronic hyperplastic candidosis. In ‘Symposium on Candida Infections’, 138.H. I. Winner &Rosalinde Hurley, Eds. xii + 249 pp. E. & S. Livingstone, Ltd., London.Google Scholar
  9. 9.
    Clayton, Yvonne M., &Noble, W. C. (1966) Observations on the epidemiology ofCandida albicans.J. Clin. Path. 19:76.Google Scholar
  10. 10.
    DiMenna, Margaret C. (1954) Non-pathogenic yeasts on the human skin and alimentary tract: a comparative survey.J. Path. Bact. 68:89.Google Scholar
  11. 11.
    Ewing, A. (1967) Amphotericin B lozenges in the treatment of oral thrush.Practitioner 199:62.Google Scholar
  12. 12.
    Fox, E. C., &Ainsworth, G. C. (1958) A contribution to the mycology of the mouth.Brith. Med. J. 1958—II:826.Google Scholar
  13. 13.
    Frostell, G. (1955) The effect in vitro of cetyl pyridinium chloride (Biosept) on oral strains ofCandida albicans.Svensk Tandlak T. 48:325.Google Scholar
  14. 14.
    Gergely, L., &Uri, J. (1961) The mycotic flora of the healthy mouth.Arch. Oral Biol. 3:125.Google Scholar
  15. 15.
    Gergely, L., &Uri, J. (1966) Day-to-day variation in the mycotic flora of the mouth. Ibid. 11:55.Google Scholar
  16. 16.
    Harris, H. J. (1950) Aureomycin and chloramphenicol in brucellosis with special reference to side effects.J. A. M. A. 142:161.Google Scholar
  17. 17.
    Holt, R. J., &Newman, R. L. (1967) Candida in the feces of children receiving tetracycline and phenoxymethyl penicillin.J. Clin. Path. 20:80.Google Scholar
  18. 18.
    Howell, A., Stephen, R. M. &Paul Frances. (1962) Prevalence ofActinomyces israelii, A. naeslundii, Bacterionema matruchotii, andCandida albicans in selected areas of the oral cavity and salvia.J. Dent. Res. 41:1050.Google Scholar
  19. 19.
    Kapica, L., Shaw, C. E. &Bartlett, G. W. (1969) Inhibition ofHistoplasma capsulatum byCandida albicans and other yeasts on Sabouraud's agar media.J. Bact., 95:2171.Google Scholar
  20. 20.
    Kilbrick, S. (1966) Lesions of the mouth. Current PediatricTherapy 1966–1967:227.Google Scholar
  21. 21.
    Krasse, B. (1955) Relationship between lactobacilli,Candida and streptococci and dental caries. Examination of saliva and plaque material collected on the same occasion.J. Dent. Ass. South Africa 10:416.Google Scholar
  22. 22.
    Kraus, F. W., &Gaston, Carolyn (1956) Individual constancy of numbers among the oral flora.J. Bact. 71:703.Google Scholar
  23. 23.
    Larsh, H. W. (1962) The prevalence and drug resistance ofHistoplasma capsulatum andCandida albicans in patients with pulmonary histoplasmosis.Lab. Invest. 11:1140.Google Scholar
  24. 24.
    Lehner, T. (1966) Classification and clinico-pathological features of Candida infections in the mouth. In ‘Symposium of Candida Infections’: 119.H. I. Winner &Rosalinde Hurley, Eds. xii+249pp. E. & S. Livingstone, Les., London.Google Scholar
  25. 25.
    McKendrick, A. J. W., Wilson, M. I. &Main, D. M. G. (1967) Oral Candida and long-term tetracycline therapy.Arch. Oral Biol. 12:281.Google Scholar
  26. 26.
    Mackenzie, D. W. R. (1961) Yeasts from human sources.Sabouraudia 1:8.Google Scholar
  27. 27.
    Mankowski, Z. T. (1954) The influence of sex hormones on experimental fungus infections.Antibiot. and Chemother. 4:1100.Google Scholar
  28. 28.
    Marples, Mary J., &DiMenna, Margaret (1952) The incidence ofCandida albicans in Dunedin, New Zealand.J. Path. Bact. 64:497.Google Scholar
  29. 29.
    Mehnert, Brigette, &Mehnert, H. (1958) Yeasts in urine and saliva of diabetic and nondiabetic patients.Diabetes 7:293.Google Scholar
  30. 30.
    Muhlens, K. (1955) Die Mykosen der Schleimhaute und inneren Organe und ihre therapeutische Beeinflussung.Med. Klin. 50:1415.Google Scholar
  31. 31.
    Orie, N. G. M., Scheda, R., Mulder-deJong, M. T. &Kikstra, A. (1966) The origin of yeasts from sputum.Scand. J. Resp. Dis. 47:85.Google Scholar
  32. 32.
    Pagano, J., Levin, J. D. &Trejo, W. (1958) Diagnostic medium for differentiation of species ofCandida.Antibiot. Ann. 1957–1958:137.Google Scholar
  33. 33.
    Paine, T. F. (1952) In vitro experiments withMonilia andEscherichia coli to explain moniliasis in patients receiving antibiotics.Antibiot. and Chemother., 2:654.Google Scholar
  34. 34.
    Peters, R. B., Barens, Gaida &Bahn, A. N. (1966)Candida albicans in the oral cavities of diabetics.J. Dent. Res. 45:771.Google Scholar
  35. 35.
    Rao, G. R., Ramakrishnan, T. &Sirsi M. (1960) Enzymes ofCandida albicans, I. Pathways of glucose dissimilation.J. Bact. 80:654.Google Scholar
  36. 36.
    Richardson, R. L., &Jones, M. (1958) A bacteriologic census of human saliva.J. Dent. Res. 37:697.Google Scholar
  37. 37.
    Rosebury, T. (1962) Microorganisms indigenous to man. xiv+435 pp. Blakiston Div. McGraw-Hill Book Co., New York.Google Scholar
  38. 38.
    Rosebury, T., Gale, D. &Taylor, D. F. (1954) An approach to the study of interactive phenomena among microorganisms indigenous to man.J. Bact. 67:135.Google Scholar
  39. 39.
    Seltzer, S., &Bender, I. B. (1949) The efficacy of various drugs againstMonilia albicans isolated from the root canals of an infected pulpless tooth.Oral Surg. 2:799.Google Scholar
  40. 40.
    Smits, B. J., Prior, A. P. &Arblaster, P. G. (1966) Incidence ofCandida in hospital in-patients and the effects of antibiotic therapy.Brit. Med. J. 1966-I:208.Google Scholar
  41. 41.
    Vanbreuseghem, R. (1958) Les infections mycotiques consécutives à l'antibiothérapie. 189 pp., Press Acad. Européennne, Brussels.Google Scholar
  42. 42.
    Van Winkle, M. G., Rheins, M. S. &Suie, T. (1964) Effects of antibiotics on experimentalCandida corneal infections.Amer. J. Ophthalmol. 57:84.Google Scholar
  43. 43.
    Von Grimmer, H. (1954) Antibiotika und Pilzerkrankungen der Haut und Schleimhaut.Antibiot. et Chemother. (Basel) 1:180.Google Scholar
  44. 44.
    Weinstein, I. W., Duke, L., B. Peters, R. S. &Bahn, A. N. (1959)Candida albicans in the saliva of diabetics.J. Dent. Res. 38:656.Google Scholar
  45. 45.
    Williams, N. B., Eickenberg, C. F. &Florey, Beverly M. (1953) A preliminary report on the quantitative interrelationships of microorganisms cultivable from human saliva.J. Dent. Res. 32:691.Google Scholar
  46. 46.
    Woods, J. W., Manning, I. H. &Patterson, C. N. (1951) Monilia infections complicating therapeutic use of antibiotics.J. A. M. A. 145:207.Google Scholar
  47. 47.
    Young, Genevieve, Krasner, R. I. &Yudkofski, P. L. (1956) Interaction of oral strains of Candida albicans and lactobacilli.J. Bact. 72:525.Google Scholar
  48. 48.
    Young, Genevieve, Resca, H. G. &Sullivan, M. T. (1951) The yeasts of the normal mouth and their relation to salivary activity.J. Dent. Res. 30:246.Google Scholar
  49. 49.
    Zimmerman, L. E. (1950)Candida andAspergillus endocarditis.Arch. Path. 50:591.Google Scholar

Copyright information

© Dr. W. Junk N.V. Den Haag 1971

Authors and Affiliations

  • J. A. Schmitt
    • 1
  1. 1.Columbus

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