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Production of glycoprotein by Candida albicans in a synthetic medium and its influence on the growth of newborn mice

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Summary

Growth ofCandida albicans on a synthetic medium for a period of 6 weeks produces glycoprotein substance in the approximate amount of 150 mg per liter. The polysaccharide component is formed by glucose and mannose in the approximate ratio 3:1. The protein component is composed of at least 15 different amino acids. Half percent of glucosamine was also found. The glycoprotein substance is water soluble and toxic to Swiss mice. LD50 is 0.75 mg/g of body weight when injected intravenously. Subcutaneous injection to newborn Swiss mice produced inhibition of growth. The degree of inhibition varied with the dosage. On one occasion when using a small amount of compound, stimulation of growth was also seen.

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Authors and Affiliations

  1. Western Institute for Cancer and Leukemia Research, Santa Monica, California

    Z. Thaddeus Mankowski M.D.

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  1. Z. Thaddeus Mankowski M.D.
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This work was supported by Damon Runyon Memorial Fund Grant 720 and Joan Sloan Memorial Fund.

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Mankowski, Z.T. Production of glycoprotein by Candida albicans in a synthetic medium and its influence on the growth of newborn mice. Mycopathologia et Mycologia Applicata 34, 113–118 (1968). https://doi.org/10.1007/BF02051419

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  • DOI: https://doi.org/10.1007/BF02051419

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