Summary
The authors have studied the fungistatic action in vitro of N,N'-bis-n-butylamide of 2,2' dicarboxydiphenyldisulfide (OD 507) on some strains ofC. albicans, C. neoformans, M. apiospermum, H. duboisii, P. pedrosoi andE. coronata isolated from human fungal infections (both superficial and deep) in Congo.
Considering that this substance has an important fungistatic action on the strains studied and that its inhibitory action maintains itself satisfactorily even in presence of human blood (though to somewhat lesser extent), the authors think it usefull to report the results obtained and suggest further research on animals with a view to investigate the possibility of using this substance parenterally on deep human fungal infections.
Résumé
Les Auteurs ont étudié l'action fungistatique “in vitro” du N,N'-bis-n.butylamide du 2,2' dicarboxydiphenyldisulfure (OD 507) sur quelques souches deC. albicans, C. neoformans, M. apiospermum H. duboisii, P. pedrosoi etE. coronata isolées au Congo à partir de mycoses humaines superficielles et profondes.
Ayant constaté que cette substance présente une action fungistatique importante sur les souches étudiées et que l'action inhibitrice, bien que moins forte, se maintient satisfaisante même en présence de sang humain, les Auteurs estiment utile de signaler les résultats obtenus et de suggérer des espériences ultérieures sur l'animal afin d'évaluer les possibilités éventuelles d'un usage parenteral de l'OD 507 dans les cas de mycose humaine profonde.
Riassunto
Gli A.A. hanno studiato l'azione fungistatica „in vitro” del N,N'-bis-n.butilamide del 2,2'dicarbossidifenildisolfuro (OD 507) su alcuni ceppi diC. albicans, C. neoformans, M. apiospermum, H. duboisii, P.pedrosoi edE. coronata isolati in Congo a partire da micosi umane supericiali e profonde.
Avendo constatato che tale sostanza presenta una notevole azione fungistatica sui ceppi studiati e che l'azione inibitrice, benchè in minor grado, si mantiene soddisfacente anche in presenza di sangue umano, ritengono utile di segnalare i risultati da loro ottenuti e di suggerire delle ulteriori esperienze sull'animale onde indagare le eventuali possibilità di impiego parenterale dell'OD 507 nelle micosi umane profonde.
Similar content being viewed by others
References
Bras, G., Gordon, C., Emmons, C. W., Prendegast, K. M. &Sugar, M. (1965). Amer. J. trop. Med. Hyg.14, 1: 141–145.
Bridges, C. H., Romane, W. M. &Emmons, C. W. (1962). J.A.V.M.A.140, 7: 673–677.
Emmons, C. W. &Bridges, C. H. (1961). Mycologia53; 3: 307–312.
Gialdi, F., Ponci, R. &Caccialanza, P. (1964). Mycopathol. et Mycol. appl.24: 164–171.
Vandepitte, J., Renoirte, R. &Gatti, F. 1966. Bull. Soc. Path. exot.58, 5: 847–862.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gatti, F., Ceballos, J. & Rossetti, C. Contribution to the study of fungistatic action of N,N'-bis-n-butylamid of 2,2' dicarboxydiphenyldisulfide (OD 507). Mycopathologia et Mycologia Applicata 34, 6–10 (1968). https://doi.org/10.1007/BF02050838
Issue Date:
DOI: https://doi.org/10.1007/BF02050838