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Inhibitory effect of calcium on carcinogenesis at the site of colonic anastomosis

An experimental study

  • Original Contributions
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: A study was made to assess the effect of oral calcium supplementation on colorectal carcinogenesis at the colocolic suture line and in the rest of the colon following administration of a carcinogen. METHODS: Fifty-nine rats were randomly divided into two groups: control (given a standard diet for rats and mice containing 0.8 percent calcium) and treatment (given the same diet as before but with 2 percent calcium). Carcinogenesis was induced by 26 weekly injections of 1,2-dimethylhydrazine. All animals were subjected to an end-to-end colonic anastomosis at the beginning of the experiment using five stitches of steel wire. RESULTS: The control group developed significantly more tumors per animal at both the anastomosis ( P < 0.001) and in the rest of the colon ( P <0.001). In addition, the percentage of rats with tumors was significantly higher in the control group at both the anastomosis (chi-squared=12; df=1,P <0.001) and in the rest of the colon (chisquared=7.12; df=1,P <0.01). The mean surface of tumors was likewise greater in the control group at the anastomosis ( P <0.001) and throughout the rest of the colon ( P <0.001). Finally, there were significantly more small-bowel tumors (excluding the duodenum) in the control group ( P <0.05). CONCLUSIONS: It is concluded that calcium supplementation decreases the tumor yield at the site of end-to-end colonic anastomosis and in the rest of the colon and small bowel (excluding the duodenum).

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Authors and Affiliations

  1. Service of Surgery, Castellón General Hospital, Castellón, Spain

    R. Adell-Carceller Ph.D., M. Segarra-Soria M.D., J. Gibert-Jerez Ph.D., J. L. Salvador Sanchís Ph.D., R. Lázaro-Santander M.D., J. Escrig-Sos Ph.D. & J. Ruiz-Castillo Ph.D.

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  1. R. Adell-Carceller Ph.D.
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  2. M. Segarra-Soria M.D.
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  3. J. Gibert-Jerez Ph.D.
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  4. J. L. Salvador Sanchís Ph.D.
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  5. R. Lázaro-Santander M.D.
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  6. J. Escrig-Sos Ph.D.
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Adell-Carceller, R., Segarra-Soria, M., Gibert-Jerez, J. et al. Inhibitory effect of calcium on carcinogenesis at the site of colonic anastomosis. Dis Colon Rectum 40, 1376–1381 (1997). https://doi.org/10.1007/BF02050826

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  • DOI: https://doi.org/10.1007/BF02050826

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