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Pathogenicity in mice of strains of Candida albicans (Robin) Berk. Isolated from burn patients

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Abstract

Three strains ofCandida albicans, isolated from burn patients who succumbed to systemic candidiasis, were studied in random-bred Swiss white mice to determine their relative pathogenicity and their histopathology. The most virulent strain caused 89.5 % mortality, compared to 70 % and 65 % at 21 days for the other two strains. Histopathological studies showed extensive involvement of the kidneys, with heavy colonization of the renal pelvis; pseudomycelia, budding cells, and blastospores were observed in all animals that died. Animals surviving after 21 days were sacrificed; no extreme pathological reaction nor cells ofC. albicans could be detected.

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Authors
  1. Marianita M. Albano
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  2. J. A. Schmitt
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Additional information

Paper No. 673, Dept. of Botany, Ohio State Univ., 1735 Neil Ave., Columbus, 43210; based, in part, on a thesis presented in partial fulfillment of the M.Sc. degree.

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Albano, M.M., Schmitt, J.A. Pathogenicity in mice of strains of Candida albicans (Robin) Berk. Isolated from burn patients. Mycopathologia et Mycologia Applicata 49, 283–288 (1973). https://doi.org/10.1007/BF02050722

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  • DOI: https://doi.org/10.1007/BF02050722

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